Mitochondrial genome sequences support ancient population expansion in Plasmodium vivax
Mitochondrial genome sequences support ancient population expansion in Plasmodium vivax
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DOI：
10.1093/molbev/msi168
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发表时间：
2005-08-01
影响因子：
10.7
通讯作者：
Hughes, AL
中科院分区：
文献类型：
--
作者：
Jongwutiwes, S;Putaporntip, C;Hughes, AL
对地理上分布最广的人类疟疾寄生虫间日疟原虫106个线粒体基因组核苷酸多样性的研究显示，其多样性水平与人类恶性疟原虫相似，但略高于恶性疟原虫。线粒体基因组序列中核苷酸差异的成对分布支持了这两种寄生虫都经历过古代种群扩张的假设。我们估计间日疟原虫和恶性疟原虫线粒体基因组最近的共同祖先（MRCA）的年龄大约在20万至30万年前。这与先前对人类线粒体MRCA和现代智人起源时间的估计接近，与这两种疟原虫在现代智人起源之前都是原始人谱系的寄生虫的假设一致，并且它们的种群扩张与它们的宿主种群扩张相吻合。
Examination of nucleotide diversity in 106 mitochondrial genomes of the most geographically widespread human malaria parasite, Plasmodium vivax, revealed a level of diversity similar to, but slightly higher than, that seen in the virulent human malaria parasite Plasmodium falciparum. The pairwise distribution of nucleotide differences among mitochondrial genome sequences supported the hypothesis that both these parasites underwent ancient population expansions. We estimated the age of the most recent common ancestor (MRCA) of the mitochondrial genomes of both P. vivax and P. falciparum at around 200,000-300,000 years ago. This is close to the previous estimates of the time of the human mitochondrial MRCA and the origin of modem Homo sapiens, consistent with the hypothesis that both these Plasmodium species were parasites of the hominid lineage before the origin of modem H. sapiens and that their population expansion coincided with the population expansion of their host.