Molecular basis for the generation in pigs of influenza A viruses with pandemic potential
Molecular basis for the generation in pigs of influenza A viruses with pandemic potential
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DOI：
10.1128/jvi.72.9.7367-7373.1998
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发表时间：
1998-09-01
影响因子：
5.4
通讯作者：
Kawaoka, Y
中科院分区：
文献类型：
--
作者：
Ito, T;Couceiro, JNSS;Kawaoka, Y
遗传和生物学观察表明，猪可能是人-禽流感病毒重组体产生的“混合容器”，类似于1957年和1968年的大流行。在这里，我们论证了这一假设的结构基础。在猪气管中发现了人和禽流感病毒的细胞表面受体，为病毒复制和基因重组提供了有利的环境。令人惊讶的是，随着不断的复制，一些类似禽类的猪病毒获得了识别人类病毒受体的能力，增加了它们直接传播给人类群体的可能性。这些发现有助于解释大流行性流感病毒的出现，并支持继续监测猪只携带禽流感病毒基因的病毒的必要性。
Genetic and biologic observations suggest that pigs may serve as "mixing vessels" for the generation of human-avian influenza A virus reassortants, similar to those responsible for the 1957 and 1968 pandemics. Here we demonstrate a structural basis for this hypothesis. Cell surface receptors for both human and avian influenza viruses were identified in the pig trachea, providing a milieu conducive to viral replication and genetic reassortment. Surprisingly, with continued replication, some avian-like swine viruses acquired the ability to recognize human virus receptors, raising the possibility of their direct transmission to human populations. These findings help to explain the emergence of pandemic influenza viruses and support the need for continued surveillance of swine for viruses carrying avian virus genes.