Lack of association between HLA and asymptomatic SARS-CoV-2 infection.
Lack of association between HLA and asymptomatic SARS-CoV-2 infection.
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HLA 与无症状 SARS-CoV-2 感染之间缺乏关联。
DOI：
10.1101/2023.12.06.23299623
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Burdet,
中科院分区：
文献类型：
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作者：
Marchal,Astrid;Cirulli,ElizabethT;Neveux,Iva;Bellos,Evangelos;Thwaites,RyanS;SchiaborBarrett,KellyM;Zhang,Yu;Nemes-Bokun,Ivana;Kalinova,Mariya;Catchpole,Andrew;Tangye,StuartG;Spaan,AndrásN;Lack,JustinB;Ghosn,Jade;Burdet,
对重症COVID-19肺炎的人类遗传学研究揭示了I型干扰素依赖性先天免疫对SARS-CoV-2感染的重要作用。相反，最近报道了HLA-B*15：01等位基因与未接种疫苗的个体中无症状SARS-CoV-2感染之间的关联，表明预先存在的T细胞依赖性适应性免疫的贡献。我们报告了在美国进行的一项基于人群的前瞻性研究中，经典HLA等位基因（包括HLA-B*15：01）与未接种疫苗的参与者中的前omicron无症状SARS-CoV-2感染缺乏关联（191例无症状vs. 945例有症状COVID-19病例）。此外，我们在国际COVID人类遗传努力队列（206例无症状vs. 574例轻度或中度COVID-19病例和1，625例重度或危重COVID-19病例）中没有发现这种关联。最后，在人类挑战表征研究中，三名感染SARS-CoV-2的HLA-B*15：01个体出现了症状。与其他急性原发性感染一样，没有发现有利于SARS-CoV-2感染无症状过程的经典HLA等位基因。这些发现表明，对季节性冠状病毒的记忆性T细胞免疫不会强烈影响未接种疫苗的个体的SARS-CoV-2感染结果。
Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B*15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, including HLA-B*15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the US (191 asymptomatic vs. 945 symptomatic COVID-19 cases). Moreover, we found no such association in the international COVID Human Genetic Effort cohort (206 asymptomatic vs. 574 mild or moderate COVID-19 cases and 1,625 severe or critical COVID-19 cases). Finally, in the Human Challenge Characterisation study, the three HLA-B*15:01 individuals infected with SARS-CoV-2 developed symptoms. As with other acute primary infections, no classical HLA alleles favoring an asymptomatic course of SARS-CoV-2 infection were identified. These findings suggest that memory T-cell immunity to seasonal coronaviruses does not strongly influence the outcome of SARS-CoV-2 infection in unvaccinated individuals.