Extravascular fluid uptake during cardiopulmonary bypass in hypertensive dogs.
Extravascular fluid uptake during cardiopulmonary bypass in hypertensive dogs.
复制标题
高血压犬体外循环期间血管外液体的摄取。
DOI：
10.1016/0003-4975(94)90216-x
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Brunner,MJ
中科院分区：
文献类型：
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作者：
Wolfer,RS;Bishop,GG;Burdett,MG;Shigemi,K;Freeman,JP;Krasna,MJ;McLaughlin,JS;Brunner,MJ
我们研究了中心静脉压（CVP）和颈动脉压力感受器诱导的血管舒张对正常血压和Goldblatt高血压犬体外循环期间血管外液体摄取率的影响。选择性灌注颈动脉窦压力感受器以控制血管舒张水平。通过改变静脉流出道插管的高度来控制中心静脉压。血管外液体摄取由储血器容积的变化率确定。转流3小时后，正常血压犬的总液体蓄积量为56.11 ± 14.16 mL/kg，显著低于高血压犬（110.90 ± 23.20 mL/kg）（p< 0.05）。将中心静脉压从1 mm Hg提高到5 mm Hg，正常血压犬（从0.05 ± 0.25 mL · kg-1· min-1提高到0.85 ± 0.22 mL · kg-1· min-1;p< 0.05）和高血压犬（从0.68 ± 0.28 mL·kg-1· min-1提高到2.57 ± 0.46 mL · kg-1· min-1;p< 0.01）的血管外液体摄取率均增加。在恒定的CVP下，压力感受器诱导的血管舒张增加了正常血压犬（从0.25 ± .15增至0.81 ± .22 mL · kg-1· min-1）和高血压犬（从0.84 ± .12增至1.72 ± .32 mL · kg-1· min-1;p< 0.05）的血管外液体摄取率。高血压犬对CVP的变化和压力感受器引起的血管舒张反应更敏感。这项研究的结果表明，CVP升高或使用血管扩张剂可能会导致增加血管外液体摄取在旁路;这种影响可能会加剧高血压状态。
We investigated the effects of increases in central venous pressure (CVP) and carotid baroreceptor-induced vasodilation on the rate of extravascular fluid uptake during cardiopulmonary bypass in normotensive and Goldblatt hypertensive dogs. Carotid sinus baroreceptors were selectively perfused to control the level of vasodilation. Central venous pressure was controlled by changing the height of the venous outflow cannula. Extravascular fluid uptake was determined from the rate of change in reservoir volume. After 3 hours of bypass, total fluid accumulation was 56.11 ± 14.16 mL/kg in normotensive dogs, significantly less than in hypertensive dogs (110.90 ± 23.20 mL/kg) (p< 0.05). Raising CVP from 1 to 5 mm Hg increased the rate of extravascular fluid uptake in both normotensive (from 0.05 ± 0.25 to 0.85 ± 0.22 mL · kg−1· min−1;p< 0.05) and hypertensive dogs (from 0.68 ± 0.28 to 2.57 ± 0.46 mL · kg−1· min−1;p< 0.01)). At a constant CVP, baroreceptor-induced vasodilation increased the rate of extravascular fluid uptake in normotensive (from 0.25 ± .15 to 0.81 ± .22 mL · kg−1· min−1) and in hypertensive dogs (from 0.84 ± .12 to 1.72 ± .32 mL · kg−1· min−1;p< 0.05). Hypertensive dogs were more sensitive to changes in CVP and to baroreceptorinduced vasodilation. The results of this study imply that elevations in CVP or the use of vasodilators may lead to increased extravascular fluid uptake during bypass; this effect may be exacerbated in the hypertensive state.