Protective roles of free avian respiratory macrophages in captive birds.
Protective roles of free avian respiratory macrophages in captive birds.
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DOI：
10.1186/s40659-016-0090-7
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发表时间：
2016-06-16
影响因子：
6.7
通讯作者：
Gicheru MM
中科院分区：
文献类型：
--
作者：
Mutua MP;Muya S;Gicheru MM
在哺乳动物的肺部，呼吸道巨噬细胞提供了抵御入侵病原体和颗粒物的前线防御。在鸟类中，呼吸道巨噬细胞被称为游离鸟类呼吸道巨噬细胞（FARM），据称鸟类肺部细胞的缺乏注定了肺部第一道防线薄弱，这种情况与家禽因呼吸道疾病引起的高死亡率有关。鸟类的肺部机制包括三层空气动力过滤系统、紧密的上皮连接和有效的粘液纤毛自动扶梯系统，已知可以补充 FARM 的保护作用。然而，目前的研究报告 FARM 表现出异常高效的吞噬能力，并能有效消除入侵的病原体。在这篇综述中，我们还报告了选择性合成的过氧化物酶体增殖物激活受体 γ (PPAR γ) 激动剂对 FARM 中非炎性吞噬特性的影响。为了开发针对 FARM 的有效治疗干预措施来治疗和管理家禽呼吸系统疾病，需要进一步研究以充分了解 FARM 在先天和适应性免疫反应中的作用。
In the mammalian lung, respiratory macrophages provide front line defense against invading pathogens and particulate matter. In birds, respiratory macrophages are known as free avian respiratory macrophages (FARM) and a dearth of the cells in the avian lung has been purported to foreordain a weak first line of pulmonary defense, a condition associated with high mortality of domestic birds occasioned by respiratory inflictions. Avian pulmonary mechanisms including a three tiered aerodynamic filtration system, tight epithelial junctions and an efficient mucociliary escalator system have been known to supplement FARM protective roles. Current studies, however, report FARM to exhibit an exceptionally efficient phagocytic capacity and are effective in elimination of invading pathogens. In this review, we also report on effects of selective synthetic peroxisome proliferator activated receptor gamma (PPAR γ) agonists on non phlogistic phagocytic properties in the FARM. To develop effective therapeutic interventions targeting FARM in treatment and management of respiratory disease conditions in the poultry, further studies are required to fully understand the role of FARM in innate and adaptive immune responses.