Twin closeness and co-twin risk for substance use disorders: assessing the impact of the equal environment assumption.
Twin closeness and co-twin risk for substance use disorders: assessing the impact of the equal environment assumption.
复制标题
双胞胎亲密关系和物质使用障碍的共同双胞胎风险：评估平等环境假设的影响。
DOI：
10.1016/s0165-1781(97)03045-x
复制
发表时间：
1997
影响因子：
11.3
通讯作者：
Pickens,RW
中科院分区：
文献类型：
--
作者：
LaBuda,MC;Svikis,DS;Pickens,RW
Various environmental variables are hypothesized to operate differentially within identical and fraternal twin pairs. To the extent that these factors are correlated with behavioral outcomes, such as alcohol or drug abuse, traditional twin studies of concordance may be biased. Self-ratings of within-pair emotional closeness, assessed in 169 same-sex twin pairs ascertained through alcohol and drug treatment centers, were used to determine the impact of the twin relationship on concordance for alcohol dependence (N=130 twin pairs) and other drug abuse and/or dependence (N=85 twin pairs). In general, identical twin pairs reported significantly closer relationships than fraternal twin pairs, and female twin pairs reported significantly closer relationships than male twin pairs. The data did not indicate an overall effect of closeness on co-twin risk for alcohol dependence. In contrast, closeness was significantly related to co-twin risk for other drug abuse and/or dependence. However, the MZ/DZ concordance difference for other drug abuse and/or dependence remained significant when the effects of within-pair closeness were controlled. Thus, the initial zygosity and sex differences in concordance for substance use disorders cannot be explained solely by differences in twin relationship due to closeness as assessed in this study.© 1997 Elsevier Science Ireland Ltd.
