Moderation of lactulose-induced diarrhea by psyllium: effects on motility and fermentation
Moderation of lactulose-induced diarrhea by psyllium: effects on motility and fermentation
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DOI：
10.1093/ajcn/67.2.237
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发表时间：
1998-02-01
影响因子：
7.1
通讯作者：
Spiller, RC
中科院分区：
文献类型：
--
作者：
Washington, N;Harris, M;Spiller, RC
据报道，车前子可抑制乳果糖诱导的结肠团块运动，并有益于肠易激综合征患者，改善便秘和腹泻。我们的目的是通过使用伽马射线照相术来确定欧车前是如何改变放射性标记的含乳果糖的试验餐的全肠转运的。8名受试者参加了一项随机交叉研究，比较了每天三次服用20 mt乳果糖（含或不含3.5 g车前子）后的胃排空和小肠及结肠运输。欧车前显著延迟胃排空：达到50%排空的时间从对照值69 +/- 9分钟增加到87 +/- 11分钟（（x）在条形图+/- SEM上; P < 0.05，n = 8）。小亭过境不变。然而，通过结肠的进展随着24小时时升结肠（对照组：2 +/-3%，车前子组：11 +/- 8%; P < 0.02）和横结肠（对照组：5 +/-12%，车前子组：21 +/- 14%）中剂量百分比的增加而延迟，降结肠中相应较少。尽管50%的同位素到达结肠的时间与欧车前没有显著差异，但欧车前显著延迟了呼吸氢浓度的上升，与对照值155 +/- 27分钟相比，其在217 +/- 34分钟达到峰值的50%（P < 0.05）。车前子可能通过增加膳食粘度来延迟胃排空，并且可能通过延迟气体发酵产物的产生来降低结肠运输的加速。
Psyllium has been reported to inhibit lactulose-induced colonic mass movements and to benefit patients with irritable bowel syndrome, improving both constipation and diarrhea. Our aim was to define how psyllium modified the whole-gut transit of a radiolabeled lactulose-containing test meal by using gamma scintigraphy. Eight subjects participated in a randomized crossover study comparing gastric emptying and small bower and colonic transit after consumption of 20 mt lactulose three times daily with or without 3.5 g psyllium three times daily. Psyllium significantly delayed gastric emptying: the time to 50% emptying increased from a control value of 69 +/- 9 to 87 +/- 11 min ((x) over bar +/- SEM; P < 0.05, n = 8). Small bower transit was unaltered. However, progression through the colon was delayed with an increase in the percentage of the dose at 24 h in the ascending (control group: 2 +/- 3%, psyllium group: 11 +/- 8%; P < 0.02) and transverse colon (control group: 5 +/- 12%, psyllium group: 21 +/- 14%) with correspondingly less in the descending colon. Although the time for 50% of the isotope to reach the colon was not significantly different with psyllium, psyllium significantly delayed the rise in breath-hydrogen concentrations, which reached 50% of their peak at 217 +/- 34 min compared with control values of 155 +/- 27 min (P < 0.05). Psyllium delays gastric emptying, probably by increasing meal viscosity, and reduces the acceleration of colon transit, possibly by delaying the production of gaseous fermentation products.