Surface-initiated polymerization of L-lactide: Coating of solid substrates with a biodegradable polymer
Surface-initiated polymerization of L-lactide: Coating of solid substrates with a biodegradable polymer
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DOI：
10.1021/ma010148i
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发表时间：
2001-07-31
期刊：
影响因子：
5.5
通讯作者：
Langer, R
中科院分区：
文献类型：
--
作者：
Choi, IS;Langer, R
我们描述了一种使用可生物降解聚合物聚乳酸（PLA）薄膜（< 100 nm）涂覆固体基质的方法，该方法结合使用自组装单分子层（SAM）和L-丙交酯（LA）与辛酸锡（II）（Sn（Oct）2）的表面引发聚合。 1 在本研究中，SAM 的形成以羟基或胺基为末端，在固体基质上呈现明确的结构和化学图案，从而可以实现进一步的化学修饰，例如表面引发的聚合。已经研究了具有生物相容性和/或可生物降解聚合物的固体基质涂层在生物医学科学中的应用。 2, 3 例如，聚乙二醇 (PEG) 通常用作植入物的涂层，以抑制生物分子和细胞的粘附。 3a 在生物医学领域，聚合物作为涂层材料的应用范围广泛，从用于假肢装置和植入物的钝化膜到用于药物输送装置的涂层。 4 对于药物输送装置，通常需要特定厚度的高度均匀的聚合物薄膜，以形成允许预定剂量的药物的渗透薄膜，或将药物封装在可生物降解的涂层中。 PLA是目前临床上使用的少数可降解材料（如缝合线）之一，广泛应用于药物输送和组织工程领域。 6 用可生物降解的 PLA 涂覆固体基质（例如硅、金或聚合物）可能会产生聚合物涂层植入物或控释装置（例如支架2d、7 或微芯片4），用于药物输送或组织工程。涂覆的可生物降解聚合物薄膜还可以提供模型表面，以进一步研究人造表面与生物分子和细胞之间的相互作用。 2d在固体表面涂层方法中，表面引发（活性）聚合已得到深入研究。 8 表面引发聚合以比其他方法（例如旋涂或“接枝”方法8a）更可控的方式提供更坚固、致密的聚合物薄膜，并且还与软光刻、9 光刻、10 或“浸笔”纳米光刻等图案化技术兼容。 11 在此，我们报告了 LA 的表面聚合以及所得聚合物薄膜的表征。我们选择了两种已用于基于微加工技术的药物输送装置的固体表面：金和硅表面。 4 这些表面和其他表面（例如玻璃和聚合物）也针对其他应用进行了深入研究，例如微机电系统 (MEMS)、微流体系统或 DNA 芯片。
We describe a method of coating solid substrates with a thin film (< 100 nm) of a biodegradable polymer, poly-(lactic acid)(PLA), using a combination of self-assembled monolayers (SAMs) and surface-initiated polymerization of L-lactide (LA) with tin (II) octoate (Sn (Oct) 2). 1 The formation of SAMs, terminated in hydroxyl or amine groups in this study, renders welldefined structural and chemical motifs on solid substrates from which further chemical modifications, such as surface-initiated polymerization, can be achieved. The coating of solid substrates with biocompatible and/or biodegradable polymers has been investigated for applications in the biomedical sciences. 2, 3 For example, poly (ethylene glycol)(PEG) is commonly used as a coating for implants to suppress the adhesion of biomolecules and cells. 3a In the biomedical field, the use of polymers as coating materials ranges from passivation films for prosthetic devices and implants to coatings for drug-delivery devices. 4 For drug-delivery devices, highly uniform polymer films of specific thickness are generally desired either to form a permeable film that allows predetermined dosage of a drug5 or to encapsulate a drug in a biodegradable coating. PLA is one of the few degradable materials currently used clinically (eg, sutures), and it is widely used in drug delivery and tissue engineering. 6 The coating of solid substrates (eg, silicon, gold, or polymers) with biodegradable PLA could potentially yield polymer-coated implants or controlled release devices (eg, a stent2d, 7 or microchip4) for applications in drug delivery or tissue engineering. The coated biodegradable polymer films could also offer model surfaces to further investigate the interactions between man-made surfaces and biomolecules and cells. 2dAmong the methods for coating solid surfaces, surfaceinitiated (living) polymerization has been intensively studied. 8 Surface-initiated polymerization gives more robust, dense polymer films in a more controlled manner than other methods such as spin-casting or the “grafting-onto” approach8a and is also compatible with patterning techniques such as soft lithography, 9 photolithography, 10 or “dip-pen” nanolithography. 11 Here we report the polymerization of LA from surfaces and the characterization of the resulting polymer films. We chose two solid surfaces that have been used for microfabrication technique-based drug delivery devices: gold and silicon surfaces. 4 These and other surfaces (eg, glass and polymers) also have been intensively studied for other applications such as microelectromechanical systems (MEMS), microfluidic systems, or DNA chips.