Cigarette smoking reduces deep retinal vascular density
Cigarette smoking reduces deep retinal vascular density
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DOI：
10.1111/cxo.13070
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发表时间：
2020-04-13
影响因子：
1.9
通讯作者：
Gobeka, Hamidu Hamisi
中科院分区：
文献类型：
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作者：
Febo, Mustafa Dogan;Akdogan, Muberra;Gobeka, Hamidu Hamisi
本研究的目的是报道吸烟对视网膜血管参数的影响。方法在横断面研究设计中，24名吸烟者作为研究组，26名年龄和性别匹配的非吸烟者作为对照组。所有参与者均接受详细的眼科检查，包括病史回顾、视力测试、Goldmann眼压测量、眼球运动和瞳孔反射检查、裂隙灯生物显微镜检查以及眼底扩张镜检查。参与者使用RTVue XR Avanti AngioVue OCT-A （Optovue, Fremont， CA， USA）进行光学相干断层扫描血管造影（OCT-A）扫描，并使用AL扫描（Nidek Co., Ltd, Gamagori, Japan）测量轴向长度。结果研究组男性18例，女性6例，平均年龄28.1 +/- 4.8岁；对照组男性19例，女性7例，平均年龄27.4 +/- 2.7岁。吸烟的平均暴露量为3.3±1.0包年。OCT-A观察吸烟组深毛细血管丛总血管密度、凹旁血管密度和凹周围血管密度均显著低于对照组（p分别为0.02、0.01和0.01）。结论低包年暴露也可引起视网膜血管病变。这些变化可以通过OCT-A证明，可能反映了吸烟对微血管系统的早期影响。
Background The purpose of this study was to report the effects of smoking on retinal vascular parameters.Methods In this cross-sectional study design, 24 smokers were included as a study group and 26 age- and sex-matched non-smokers as a control group. A detailed ophthalmic examination including review of medical history, visual acuity testing, intraocular pressure measurement by Goldmann applanation tonometry, ocular movement and pupillary reflex examination, slitlamp biomicroscopy as well as dilated funduscopic examination were undertaken in all participants. Participants underwent optical coherence tomography angiography (OCT-A) scanning with RTVue XR Avanti AngioVue OCT-A (Optovue, Fremont, CA, USA) as well as the measurement of axial length using an AL Scan (Nidek Co., Ltd., Gamagori, Japan).Results The study comprised of 18 men and six women with a mean age of 28.1 +/- 4.8 years in the study group and 19 men and seven women with a mean age of 27.4 +/- 2.7 years in the control group. The mean exposure to cigarette smoking was 3.3 +/- 1.0 pack-years. Total vascular density, parafoveal vascular density and perifoveal vascular density in the deep capillary plexus observed with OCT-A were significantly lower in the smoking group compared to the control group (p = 0.02, 0.01 and 0.01, respectively).Conclusion Retinal vascular changes caused by cigarette smoking may occur even at low pack-year exposure. These changes, which can be demonstrated by OCT-A, may reflect the early impact of cigarette smoking on the microvascular system.