Dopamine D1 + D3 receptor density may correlate with parkinson disease clinical features.
Dopamine D1 + D3 receptor density may correlate with parkinson disease clinical features.
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DOI：
10.1002/acn3.51274
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发表时间：
2021-01
影响因子：
5.3
通讯作者：
Xu J
中科院分区：
文献类型：
--
作者：
Yang P;Knight WC;Li H;Guo Y;Perlmutter JS;Benzinger TLS;Morris JC;Xu J
多巴胺 D2 样受体——主要是多巴胺 D2 受体 (D2R) 和多巴胺 D3 受体 (D3R)——被认为与帕金森病 (PD) 进展的病理学密切相关。然而，这些受体尚未在帕金森病患者中进行精确检查。我们的目的是定量计算对照、阿尔茨海默病 (AD) 和路易体病 (LBD) 患者（包括 PD、路易体痴呆和帕金森病痴呆）中多巴胺 D1 受体 (D1R)、D2R 和 D3R 的准确密度；并分析多巴胺受体与PD临床表现的关系。我们使用我们小组先前开发的新型定量放射自显影程序分析了纹状体和黑质 (SN) 中 D1R、D2R 和 D3R 的密度。我们还通过原位杂交检查了纹状体中 D2R 和 D3R mRNA 的表达。结果显示，虽然各组间纹状体D1R没有发现差异；与对照组和 AD 患者相比，PD 患者纹状体中的 D2R 显着降低。一些临床表现：发病年龄、PD分期、多巴胺反应性、发病后生存时间；与单独的 D1R 或 D3R 相比，与纹状体 D1R + D3R 密度组合显示出更好的相关性。我们有可能通过检测 D1R + D3R 来推断 PD 的诊断、治疗和预后结果，而不是单独使用多巴胺 D1 或 D3 受体。对于 D2R 表达低的老年患者尤其如此，这在这种疾病中很常见。
Dopamine D2‐like receptors – mainly dopamine D2 receptors (D2R) and dopamine D3 receptors (D3R) – are believed to be greatly involved in the pathology of Parkinson disease (PD) progression. However, these receptors have not been precisely examined in PD patients. Our aim was to quantitatively calculate the exact densities of dopamine D1 receptors (D1R), D2R, and D3R in control, Alzheimer disease (AD), and Lewy body disease (LBD) patients (including PD, Dementia with Lewy bodies, and Parkinson disease dementia); and analyze the relationship between dopamine receptors and clinical PD manifestations. We analyzed the densities of D1R, D2R, and D3R in the striatum and substantia nigra (SN) using a novel quantitative autoradiography procedure previously developed by our group. We also examined the expression of D2R and D3R mRNA in the striatum by in situ hybridization. The results showed that although no differences of striatal D1R were found among all groups; D2R was significantly decreased in the striatum of PD patients when compared with control and AD patients. Some clinical manifestations: age of onset, PD stage, dopamine responsiveness, and survival time after onset; showed a better correlation with striatal D1R + D3R densities combined compared to D1R or D3R alone. There is a possibility that we may infer the results in diagnosis, treatment, and prognosis of PD by detecting D1R + D3R as opposed to using dopamine D1 or D3 receptors alone. This is especially true for elderly patients with low D2R expression as is common in this disease.
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影响因子：
2.9
作者：
Joyce, JN;Ryoo, HL;Adler, CH
通讯作者：
Adler, CH
影响因子：
3.4
作者：
Collo, Ginetta;Zanetti, Silvia;Spano, PierFranco
通讯作者：
Spano, PierFranco
影响因子：
8.6
作者：
Antonini, A;Schwarz, J;Leenders, KL
通讯作者：
Leenders, KL
影响因子：
14.5
作者：
Boileau, Isabelle;Guttman, Mark;Kish, Stephen J.
通讯作者：
Kish, Stephen J.
DOI：
10.1073/pnas.94.7.3363
发表时间：
1997-04-01
影响因子：
11.1
作者：
Bordet, R;Ridray, S;Schwartz, JC
通讯作者：
Schwartz, JC