Cranial chordomas: clinical presentation and results of operative and radiation therapy in twenty-six patients.
Cranial chordomas: clinical presentation and results of operative and radiation therapy in twenty-six patients.
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颅脊索瘤：26 名患者的临床表现以及手术和放射治疗的结果。
DOI：
10.1227/00006123-198511000-00002
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发表时间：
1985
期刊：
影响因子：
4.8
通讯作者：
C. Wilson
中科院分区：
文献类型：
--
作者：
C. Raffel;D. Wright;P. Gutin;C. Wilson
本文回顾了1940年至1984年在加州大学旧金山弗朗西斯科收治的26例颅脊索瘤的临床表现、手术和放射治疗的结果。男14例，女12例，平均年龄39.6岁。软骨样脊索瘤6例。最常见的临床症状为头痛和复视，最常见的临床体征为眼外肌麻痹。进行了53次手术，旨在切除肿瘤。23例患者术后接受了各种形式的放射治疗，包括常规外照射治疗、重带电粒子和间质植入。平均随访时间为5.6年。26例患者中有11例死亡;除1例围手术期死亡外，该组的平均生存期为4年零2个月。虽然典型脊索瘤患者（不包括围手术期死亡和1例失访患者）和软骨样变异患者的平均生存时间相同，均为6年4个月，但后者均存活，而典型脊索瘤患者中有一半以上死亡。
The clinical presentation and the results of operative and radiation therapy in a series of 26 patients with cranial chordomas seen at the University of California, San Francisco, between 1940 and 1984 are reviewed. There were 14 men and 12 women, with a mean age of 39.6 years. Six patients had chondroid chordomas. The most common presenting symptoms were headache and diplopia, and the most common presenting sign was extraocular palsy. Fifty-three operations directed at removal of the tumor were performed. Twenty-three patients received various forms of radiation therapy postoperatively, including conventional external beam therapy, heavy charged particles, and interstitial implants. The average length of follow-up is 5.6 years. Eleven of 26 patients have died; the mean duration of survival in this group, excluding 1 perioperative death, was 4 years and 2 months. Although the average survival time of 6 years and 4 months was the same in patients with typical chordomas (excluding the perioperative death and 1 patient lost to follow-up) and in those with the chondroid variant, all of the latter are still alive, whereas more than half of the patients with typical chordoma have died.