Effects of selective dopaminergic compounds on a delay-discounting task.
Effects of selective dopaminergic compounds on a delay-discounting task.
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选择性多巴胺能化合物对延迟减少任务的影响。
DOI：
10.1097/fbp.0b013e3283473bcb
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发表时间：
2011-08
影响因子：
1.6
通讯作者：
Woods JH
中科院分区：
文献类型：
--
作者：
Koffarnus MN;Newman AH;Grundt P;Rice KC;Woods JH
冲动性被广泛认为是一种包含两种或两种以上不同行为模式的多维特征，多巴胺能系统与人类和动物的冲动行为表达有关。冲动选择，或倾向于选择与相对较少或没有延迟相关的奖励，已经在人类和动物中通过延迟折扣任务进行了广泛的研究。在这里，延迟折扣程序被用来评估受体选择性多巴胺能激动剂、拮抗剂和多巴胺转运体配体对即时和延迟蔗糖颗粒选择的影响。在24只Sprague Dawley大鼠身上观察d-安非他明、GBR 12909、阿波啡、SKF 81297、苏马尼罗、普拉克索、ABT-724、SCH 23390、L-741,626、PG01037、L-745,870的作用。只有d1样拮抗剂SCH 23390 （0.01 mg/kg）和D4部分激动剂ABT-724 （3.2 mg/kg）选择性地影响冲动选择而不改变未延迟选择，两者都增加了冲动选择。这些化合物的共同作用可以解释为它们在前额皮质不同组的神经元上的定位。没有一种选择性激动剂和拮抗剂测试减少冲动选择，因此需要进一步的研究来确定直接多巴胺能激动剂或拮抗剂是否可用于治疗冲动控制障碍。
Impulsivity is widely regarded as a multidimensional trait that encompasses two or more distinct patterns of behavior, and dopaminergic systems are implicated in the expression of impulsive behavior in both humans and animals. Impulsive choice, or the tendency to choose rewards associated with relatively little or no delay, has been extensively studied in humans and animals using delay discounting tasks. Here, delay discounting procedures were used to assess the effects of receptor-selective dopaminergic agonists, antagonists, and dopamine transporter ligands on choices of immediate versus delayed sucrose pellets. The effects of d-amphetamine, GBR 12909, apomorphine, SKF 81297, sumanirole, pramipexole, ABT-724, SCH 23390, L-741,626, PG01037, and L-745,870 were assessed in 24 Sprague Dawley rats. The only drugs to affect impulsive choice selectively without altering undelayed choice were the D1-like antagonist SCH 23390 (0.01 mg/kg) and the D4 partial agonist ABT-724 (3.2 mg/kg), which both increased impulsive choice. The shared effects of these compounds may be explained by their localization within the prefrontal cortex on different groups of neurons. None of the selective agonists and antagonists tested reduced impulsive choice, so further research is needed to determine if direct dopaminergic agonists or antagonists may be therapeutically useful in the treatment of impulse-control disorders.