PANACEA: An Internet of Bio-NanoThings Application for Early Detection and Mitigation of Infectious Diseases
PANACEA: An Internet of Bio-NanoThings Application for Early Detection and Mitigation of Infectious Diseases
复制标题
DOI：
10.1109/access.2020.3012139
复制
发表时间：
2020-01-01
期刊：
影响因子：
3.9
通讯作者：
Unluturk, Bige D.
中科院分区：
文献类型：
--
作者：
Akyildiz, Ian F.;Ghovanloo, Maysam;Unluturk, Bige D.
生物纳米物联网（IoBNT）概念设想了生物细胞和互联网之间的连接。IoBNT的最终目标是通过分子通信，集成系统，生物纳米传感器和合成生物学的进步来促进生物医学技术的革命，以改善人类健康和生活质量。在本文中，一个名为PANACEA（拉丁语中所有困难或疾病的解决方案或补救措施）的IoBNT应用程序被提出作为文献中首次实现IoBNT的端到端设计的解决方案。PANACEA的架构是专门针对传染病的诊断和治疗而设计的。在PANACEA中，为了检测身体细胞内的通信以推断感染水平，提出了一种亚毫米级的可植入生物电子设备，即生物纳米物。BNT可以将检测到的感染数据远程传输到体外的可穿戴集线器/网关。集线器可以使用移动的设备和诸如互联网或蜂窝系统的骨干网络来到达可以远程控制BNT的医疗保健提供者。因此，PANACEA提供了一种系统，其中感测、致动和计算过程紧密耦合，以提供可靠且响应迅速的疾病检测和感染恢复系统。分子通信和传统网络的融合带来了许多挑战，这些挑战在电路和生物传感器设计、通信工程等各个方面受到攻击，本文提出了新的解决方案，并附有仿真结果。
The Internet of Bio-NanoThings (IoBNT) concept envisions the connection between biological cells and the Internet. The ultimate goal of IoBNT is to catalyze a revolution in biomedical technologies through advances in molecular communication, integrated systems, bio-nanosensors and synthetic biology to improve human health and quality of life. In this paper, an application of IoBNT called PANACEA (a solution or remedy for all difficulties or diseases in Latin) is presented as a solution for an end-to-end design towards realizing the IoBNT for the first time in the literature. The architecture of PANACEA is tailored to focus on diagnosis and therapy of infectious diseases. In PANACEA, to detect the communication within the cells of the body to deduce infection level, a submilimeter implantable bio-electronic device, a Bio-NanoThing, is proposed. BNT can transmit the detected infection data remotely to a wearable hub/gateway outside of the body. The hub can use mobile devices and the backbone network such as Internet or cellular systems to reach the healthcare providers who can remotely control the BNTs. Hence, PANACEA provides a system, where sensing, actuation and computing processes are tightly coupled to provide a reliable and responsive disease detection and infection recovery system. Incorporating molecular communication and conventional networks brings many challenges that are attacked in various fronts such as circuit and biosensor design, communications engineering, with novel solutions presented in this paper, accompanied with simulation results.