Emerging Role of PML Nuclear Bodies in Innate Immune Signaling
Emerging Role of PML Nuclear Bodies in Innate Immune Signaling
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DOI：
10.1128/jvi.01979-15
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发表时间：
2016-07-01
影响因子：
5.4
通讯作者：
Stamminger, Thomas
中科院分区：
文献类型：
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作者：
Scherer, Myriam;Stamminger, Thomas
过去20年的研究表明，细胞核中的一种特定细胞器，称为PML核体（PML-NB）或核结构域10（ND 10），在病毒感染期间经常被修饰。这与单个PML-NB组分（如PML、hDaxx、Sp100或ATRX蛋白质）的直接抑制功能的抑制作用相关，这些组分能够充当细胞限制因子。最近的研究揭示了PML-NB作为I型和II型干扰素应答的共调节结构的新兴作用。这强调了通过病毒调节蛋白靶向PML-NB已经演变为一种策略，以损害内在的抗病毒防御和先天免疫应答。
Research in the last 2 decades has demonstrated that a specific organelle of the cell nucleus, termed PML nuclear body (PML-NB) or nuclear domain 10 (ND10), is frequently modified during viral infection. This correlates with antagonization of a direct repressive function of individual PML-NB components, such as the PML, hDaxx, Sp100, or ATRX protein, that are able to act as cellular restriction factors. Recent studies now reveal an emerging role of PML-NBs as coregulatory structures of both type I and type II interferon responses. This emphasizes that targeting of PML-NBs by viral regulatory proteins has evolved as a strategy to compromise intrinsic antiviral defense and innate immune responses.