Telomere Length and the Risk of Alzheimer's Disease: The Rotterdam Study
Telomere Length and the Risk of Alzheimer's Disease: The Rotterdam Study
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DOI：
10.3233/jad-190759
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发表时间：
2020-01-01
影响因子：
4
通讯作者：
Ikram, M. Arfan
中科院分区：
文献类型：
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作者：
Fani, Lana;Hilal, Saima;Ikram, M. Arfan
人们对捕获有害因素的负担的生物标志物有广泛的兴趣，因为这些有害因素随着时间的推移而积累，即，年龄增长。端粒长度作为这样的标志物已经受到相当大的关注，因为它很容易量化，并且它可以帮助解开痴呆的病因或作为预测标志物。我们确定了端粒长度与阿尔茨海默病和全因痴呆风险的关系。在鹿特丹研究中，我们进行了定量PCR来测量血液中的平均白细胞端粒长度。我们使用考克斯回归模型确定了2016年之前端粒长度与阿尔茨海默病风险的关系。在1，961名参与者（平均年龄71.4 ± 9.3岁，57.1%为女性）中，中位随访时间为8.3年，237人被诊断患有阿尔茨海默病。我们发现端粒长度与阿尔茨海默病风险之间存在U型关联：与中间三分位数相比，最低三分位数的调整后风险比为1.59（95%置信区间（CI），1.13-2.23），最高三分位数为1.47（1.03-2.10）。结果也是类似的U形，但对全因痴呆症略有减弱。总之，在一般人群中，较短和较长的端粒长度都与阿尔茨海默病的风险增加有关。
There is a wide interest in biomarkers that capture the burden of detrimental factors as these accumulate with the passage of time, i.e., increasing age. Telomere length has received considerable attention as such a marker, because it is easily quantified and it may aid in disentangling the etiology of dementia or serve as predictive marker. We determined the association of telomere length with risk of Alzheimer's disease and all-cause dementia in a population-based setting. Within the Rotterdam Study, we performed quantitative PCR to measure mean leukocyte telomere length in blood. We determined the association of telomere length with risk of Alzheimer's disease until 2016, using Cox regression models. Of 1,961 participants (mean age 71.4 +/- 9.3 years, 57.1% women) with a median follow-up of 8.3 years, 237 individuals were diagnosed with Alzheimer's disease. We found a U-shaped association between telomere length and risk of Alzheimer's disease: compared to the middle tertile the adjusted hazard ratio was 1.59 (95% confidence interval (CI), 1.13-2.23) for the lowest tertile and 1.47 (1.03-2.10) for the highest tertile. Results were similarly U-shaped but slightly attenuated for all-cause dementia. In conclusion, shorter and longer telomere length are both associated with an increased risk of Alzheimer's disease in the general population.