Influences of menopause, aging, and gender on the cleavage of type II collagen in cartilage in relationship to bone turnover
Influences of menopause, aging, and gender on the cleavage of type II collagen in cartilage in relationship to bone turnover
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DOI：
10.1097/gme.0b013e318054e2ce
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发表时间：
2008-01-01
影响因子：
2.7
通讯作者：
Poole, A. Robin
中科院分区：
文献类型：
--
作者：
Kojima, Toshihisa;Kojima, Masayo;Poole, A. Robin
目的：目前尚不清楚绝经后软骨更新是否有变化，尽管这些在骨中有很好的记录。本研究的目的是探讨绝经可能改变软骨转换以及骨转换的可能性。我们还检查了年龄和性别，以估计这些参数以及绝经对软骨和骨转换的独立影响。设计：血清样本收集自140名健康志愿者，69名男性，（平均年龄+/- SD，42.8 +/- 13.8岁）和71名自我报告绝经前或绝经后状态的女性（44.4 +/- 10.5岁），她们的脊柱和关节没有肿胀或疼痛。还记录了体重指数。同时测量软骨II型胶原（C2C）降解生物标志物的血清浓度以及血清骨碱性磷酸酶和尿交联I型胶原N-端肽（均为公认的骨转换生物标志物）的浓度。协方差分析进行测试的平均差异的生物标志物的性别和绝经状态与年龄adjustment.Results：在男性之间的年龄和生物标志物没有显着的相关性。女性C2C浓度随年龄增长而下降。交联I型胶原蛋白N-端肽和骨碱性磷酸酶水平均增加绝经后，而C2C没有表现出可检测的变化。C2C是没有显着相关的体重index.Conclusions：这项研究表明，有根本性的差异，在降解未钙化的C2C和骨I型胶原降解和骨组装在响应更年期和衰老。
Objective: It is unclear whether there are changes in cartilage turnover after menopause, although these are well documented in bone. The aim of this study was to explore the possibility that menopause might change cartilage turnover as well as bone turnover. We also examined age and gender to estimate the independent influences of these parameters together with menopause on cartilage and bone turnover.Design: Serum samples were collected from 140 healthy volunteers, 69 men (mean age +/- SD, 42.8 +/- 13.8 y) and 71 women (44.4 +/- 10.5 y) with self-reported pre- or postmenopausal status who had no swelling or pain in their spine and joints. Body mass index was also recorded. The serum concentration of a biomarker of cartilage type II collagen (C2C) degradation and concentrations of serum bone alkaline phosphatase and urine cross-linked type I collagen N-telopeptide, both accepted biomarkers of bone turnover, were measured together. Analyses of covariance were performed to test the mean differences of biomarkers by gender and by menopause status with age adjustment.Results: In men there were no significant correlations between age and the biomarkers. In women C2C concentration decreased with age. Cross-linked type I collagen N-telopeptide and bone alkaline phosphatase levels were both increased after menopause, whereas C2C showed no detectable changes. C2C was not significantly related to body mass index.Conclusions: This study suggests that there are fundamental differences in the degradation of uncalcified C2C and bone type I collagen degradation and bone assembly in response to menopause and aging.