Roles and regulation of lens epithelial cell connexins.
Roles and regulation of lens epithelial cell connexins.
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DOI：
10.1016/j.febslet.2013.12.024
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发表时间：
2014-04-17
期刊：
影响因子：
3.5
通讯作者：
Beyer EC
中科院分区：
文献类型：
--
作者：
Berthoud VM;Minogue PJ;Osmolak P;Snabb JI;Beyer EC
无血管的透镜前部被含有有核代谢活性细胞的上皮细胞覆盖。这种上皮细胞包含第一个遇到有害外部刺激的透镜细胞和可以产生补偿或保护反应的细胞。透镜上皮细胞表达差距连接蛋白，连接蛋白43（Cx43）和连接蛋白50（Cx50）。Cx43和Cx50形成具有不同性质的间隙连接通道和半通道。虽然Cx43和Cx50可以形成异聚半通道，但它们可能不会在透镜中形成异型通道。在出生后早期，Cx50通道对细胞间通讯的贡献最大;随后，Cx43成为支持细胞间通讯的主要连接蛋白。虽然上皮细胞Cx43对透镜的发育起重要作用，但Cx50对上皮细胞的增殖和分化至关重要。Cx43和Cx50半通道和间隙连接通道由多种不同的试剂调节，并且可能有助于正常透镜生理学和病理学。
The avascular lens of the eye is covered anteriorly by an epithelium containing nucleated, metabolically active cells. This epithelium contains the first lens cells to encounter noxious external stimuli and cells that can develop compensatory or protective responses. Lens epithelial cells express the gap junction proteins, connexin43 (Cx43) and connexin50 (Cx50). Cx43 and Cx50 form gap junction channels and hemichannels with different properties. Although they may form heteromeric hemichannels, Cx43 and Cx50 probably do not form heterotypic channels in the lens. Cx50 channels make their greatest contribution to intercellular communication during the early postnatal period; subsequently, Cx43 becomes the predominant connexin supporting intercellular communication. Although epithelial Cx43 appears dispensable for lens development, Cx50 is critical for epithelial cell proliferation and differentiation. Cx43 and Cx50 hemichannels and gap junction channels are regulated by multiple different agents and likely contribute to both normal lens physiology and to pathology.
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影响因子：
4
作者：
Banks, Eric A.;Yu, X. Sean;Jiang, Jean X.
通讯作者：
Jiang, Jean X.
影响因子：
4.4
作者：
Berthoud, Viviana M.;Minogue, Peter J.;Beyer, Eric C.
通讯作者：
Beyer, Eric C.
DOI：
10.1073/pnas.012589799
发表时间：
2002-01-08
影响因子：
11.1
作者：
Contreras, JE;Sánchez, HA;Sáez, JC
通讯作者：
Sáez, JC
影响因子：
3.4
作者：
GIBLIN, FJ;REDDAN, JR;REDDY, VN
通讯作者：
REDDY, VN
影响因子：
5.6
作者：
Bodendiek SB;Rubinos C;Trelles MP;Coleman N;Jenkins DP;Wulff H;Srinivas M
通讯作者：
Srinivas M