Long-term safety of autotransfusion during hepatectomy for hepatocellular carcinoma
Long-term safety of autotransfusion during hepatectomy for hepatocellular carcinoma
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DOI：
10.1007/s00595-005-3082-8
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发表时间：
2005-12-01
期刊：
影响因子：
2.5
通讯作者：
Fujimoto, J
中科院分区：
文献类型：
--
作者：
Hirano, T;Yamanaka, J;Fujimoto, J
目的.目的评价自体血回输（AT）在肝癌切除术中的长期安全性。1988年至1989年，46例HCC患者接受了AT肝切除术（组1）。为了比较，我们匹配了50例接受肝切除术的HCC患者，并接受了同源而非自体血液（第2组）。比较两组患者的10年累积生存曲线和无癌生存曲线，并比较两组患者的复发情况。第1组的累积10年生存率显著高于第2组，分别为20%和8%（P < 0.05）。在接受根治性切除的患者中，第1组的累积生存率和无癌生存率分别为27%和13%，明显高于第2组的11%和0%（P <0.05）。在I ~ II期HCC患者中，第1组的累积生存率和无癌生存率分别为30%和5%（P < 0.01），第2组为20%和5%（P < 0.05）。然而，两组中III-IV期疾病患者的发生率相似。两组患者的复发模式相似。自体血回输可提高I期或II期HCC行肝切除术患者的生存率。
Purpose. To evaluate the long-term safety of autotransfusion (AT) in hepatectomy for hepatocellular carcinoma (HCC).Methods. Between 1988 and 1989, 46 patients with HCC underwent hepatectomy with AT (group 1). For a comparison, we matched 50 patients with HCC who underwent hepatectomy, and received homologous but not autologous blood (group 2). The 10-year cumulative survival curves and cancer-free curves of the two groups were examined, and the pattern of recurrence was compared.Results. Group 1 had a significantly higher cumulative 10-year survival rate than group 2, at 20% vs 8%, respectively (P < 0.05). Among the patients who underwent curative resection, those in group 1 had significantly better cumulative survival and cancer-free survival rates than those in group 2, at 27% vs 11% (P < 0.05) and 13% vs 0% (P < 0.05), respectively. Among the patients with stage I-II HCC, those in group 1 had significantly better cumulative survival and cancer-free survival rates than those in group 2, at 30% vs 5% (P < 0.01) and 20% vs 5% (P < 0.05), respectively. However, the rates were similar among patients with stage III-IV disease in both groups. The pattern of recurrence in the two groups was similar.Conclusion. Autotransfusion promoted survival in patients undergoing hepatectomy for stage I or II HCC.