NOVEL 4-HYDROXYCOUMARIN ANTICOAGULANTS ACTIVE AGAINST RESISTANT RATS
NOVEL 4-HYDROXYCOUMARIN ANTICOAGULANTS ACTIVE AGAINST RESISTANT RATS
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DOI：
10.1038/253275a0
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发表时间：
1975-01-01
期刊：
影响因子：
64.8
通讯作者：
SHADBOLT, RS
中科院分区：
文献类型：
--
作者：
HADLER, MR;SHADBOLT, RS
在苏格兰、丹麦、英格兰和威尔士以及最近在美洲大陆出现了对抗凝血杀鼠剂（例如，Warfalin）具有耐药性的褐家鼠（Rattus norvegicus）野外种群。这种抗性似乎与维生素K代谢效率的降低有关，并且是由单个显性常染色体基因控制的遗传因素。人们提出了各种各样的理论来解释这一潜在的机制。对其他抗凝剂的耐药性现在已经出现，对杀鼠迷是最不有效的1。
FIELD populations of common rats (Rattus norvegicus) resistant to anticoagulant rodenticides (for example, Warfarin) have appeared1in Scotland, Denmark, England and Wales, and more recently on the American continent. This resistance seems to be associated with a reduction in the efficiency of vitamin K metabolism1and is an inheritable factor controlled by a single dominant autosomal gene. Various theories have1,2been advanced to explain the underlying mechansim. Resistance to other anticoagulants has now appeared, that to coumatetralyl being the least effective1.