Structural changes at dendritic spine synapses during long-term potentiation
Structural changes at dendritic spine synapses during long-term potentiation
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DOI：
10.1098/rstb.2002.1254
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发表时间：
2003-04-29
影响因子：
6.3
通讯作者：
Ostroff, L
中科院分区：
文献类型：
--
作者：
Harris, KM;Fiala, JC;Ostroff, L
根据未成熟大鼠海马切片的新发现，对长期增强（LTP）结构基础的两个关键假设进行了评估。首先，它显示了为什么树突棘在LTP期间不分裂。相反，少量棘状树突状突起可能会出现，以增强与增强轴突的连通性。这些“相同的树突多突触按钮”提供的连通性增加不到3%，并且不能解释所有的LTP或记忆，因为它们在成熟过程中不会积累。其次，树突棘中的多核糖体用于确定哪些现有突触扩大以维持突触强度增加30%以上。因此，在LTP期间，连通性增强和突触扩大都是结果，突触扩大的影响更大。
Two key hypotheses about the structural basis of long-term potentiation (LTP) are evaluated in light of new findings from immature rat hippocampal slices. First, it is shown why dendritic spines do not split during LTP. Instead a small number of spine-like dendritic protrusions may emerge to enhance connectivity with potentiated axons. These 'same dendrite multiple synapse boutons' provide less than a 3% increase in connectivity and do not account for all of LTP or memory, as they do not accumulate during maturation. Second, polyribosomes in dendritic spines served to identify which of the existing synapses enlarged to sustain more than a 30% increase in synaptic strength. Thus, both enhanced connectivity and enlarged synapses result during LTP, with synapse enlargement being the greater effect.