Development of morphological diversity of dendrites in Drosophila by the BTB-zinc finger protein abrupt
Development of morphological diversity of dendrites in Drosophila by the BTB-zinc finger protein abrupt
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DOI：
10.1016/j.neuron.2004.08.016
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发表时间：
2004-09-16
期刊：
影响因子：
16.2
通讯作者：
Uemura, T
中科院分区：
文献类型：
--
作者：
Sugimura, K;Satoh, D;Uemura, T
树突的形态多样性决定了单个神经元的特殊功能。在本研究中，我们研究了产生果蝇树突状树枝状(DA)神经元不同形态类型的分子基础。DA神经元按区域大小和/或分支复杂性的顺序被分为I到IV类。我们发现在第I类细胞中选择性地表达了BTB-锌指蛋白--突变(Ab)。在其他类别的神经元中，ab的错误表达引导它们呈现出具有更小和/或更不精细的茎的细胞的外观。I类神经元的ab功能丧失，导致其典型的梳状分枝模式畸形，并产生多余的分支终末。结合ab错误表达细胞和ab突变细胞的树突状动态监测结果，所有数据表明，Ab1类神经元具有树突状形态发生的特征。
Morphological diversity of dendrites contributes to specialized functions of individual neurons. In the present study, we examined the molecular basis that generates distinct morphological classes of Drosophila dendritic arborization (da) neurons. da neurons are classified into classes I to IV in order of increasing territory size and/or branching complexity. We found that Abrupt (Ab), a BTB-zinc finger protein, is expressed selectively in class I cells. Misexpression of ab in neurons of other classes directed them to take the appearance of cells with smaller and/or less elaborated arbors. Loss of ab functions in class I neurons resulted in malformation of their typical comb-like arbor patterns and generation of supernumerary branch terminals. Together with the results of monitoring dendritic dynamics of ab-misexpressing cells or ab mutant ones, all of the data suggested that Ab endows characteristics of dendritic morphogenesis of the class I neurons.