Does leptin play a role in obesity-asthma relationship?
Does leptin play a role in obesity-asthma relationship?
复制标题
DOI：
10.1111/j.1399-3038.2008.00812.x
复制
发表时间：
2009-05-01
影响因子：
4.4
通讯作者：
Krewski, Daniel
中科院分区：
文献类型：
--
作者：
Mai, Xiao-Mei;Chen, Yue;Krewski, Daniel
过去几十年来，哮喘病的增加与肥胖症的增加并行。肥胖的特征是循环中瘦素增加。瘦素是一种肥胖基因产物，它可以刺激促炎介质的产生，例如肿瘤坏死因子（TNF）-α、白细胞介素（IL）-6和干扰素（IFN）-γ。瘦素和哮喘之间存在联系，尤其是儿童。然而，目前尚不清楚瘦素是否在肥胖与哮喘关系的通路中，以及它是否在肥胖与非肥胖受试者的哮喘中发挥独特的作用。由于瘦素与促炎细胞因子（例如 TNF-α）处于正反馈循环中，因此瘦素有可能作为哮喘发展的调节机制而不是病因机制。体重减轻与儿童循环瘦素浓度降低有关。在肥胖儿童的哮喘治疗中可能需要考虑体重控制计划。
The increase of asthma has paralleled the rising obesity during the past decades. Obesity is characterized by the increase of leptin in the circulation. Leptin is an obesity gene product, and it can stimulate the production of pro-inflammatory mediators, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and interferon (IFN)-gamma. There is a link between leptin and asthma, especially in children. It remains unclear however, if leptin is in the pathway of obesity-asthma relationship and if it plays a distinctive role in asthma in obese vs. non-obese subjects. Since leptin is in a positive feedback loop with the pro-inflammatory cytokines such as TNF-alpha, there is a possibility that leptin is involved as a regulatory rather than an etiologic mechanism of asthma development. Weight loss is associated with decreased circulating leptin concentration in children. Weight control program may need to be considered in the treatment of asthma in obese children.