Sleep Disturbances Are Related to Decreased Transmission of Blue Light to the Retina Caused by Lens Yellowing
Sleep Disturbances Are Related to Decreased Transmission of Blue Light to the Retina Caused by Lens Yellowing
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DOI：
10.5665/sleep.1242
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发表时间：
2011-09-01
期刊：
影响因子：
5.6
通讯作者：
Larsen, Michael
中科院分区：
文献类型：
--
作者：
Kessel, Line;Siganos, Galatios;Larsen, Michael
研究目的：睡眠模式和昼夜节律通过视网膜下丘脑束响应于视网膜神经节细胞亚群的刺激而调节，主要是蓝光（450-490 nm）。随着年龄的增长，由于人的透镜的老化过程，蓝光到视网膜的透射减少，并且这可能损害昼夜节律的光诱导，导致睡眠障碍。本研究的目的是检查透镜老化和睡眠障碍之间的关联。设计：基于人群的横断面研究。设置：本研究在丹麦格洛斯堡医院预防和健康研究中心和丹麦Herlev医院眼科进行。参与者：从背景人口中随机抽取970名年龄在30至60岁之间的人作为年龄和性别分层样本。干预措施：不适用。通过问卷调查和使用处方睡眠药物来评估睡眠障碍，即使在校正了年龄和其他混杂因素（如吸烟习惯，糖尿病，性别，结论：老化的透镜对蓝光的过滤与睡眠障碍的风险增加显著相关。我们认为这是昼夜节律光诱导干扰的结果。
Study Objectives: Sleep pattern and circadian rhythms are regulated via the retinohypothalamic tract in response to stimulation of a subset of retinal ganglion cells, predominantly by blue light (450-490 nm). With age, the transmission of blue light to the retina is reduced because of the aging process of the human lens, and this may impair the photoentrainment of circadian rhythm leading to sleep disorders. The aims of the study was to examine the association between lens aging and sleep disorders.Design: Cross-sectional population based study.Setting: The study was performed at the Research Center for Prevention and Health, Glosrup Hospital, Denmark and at the Department of Ophthalmology, Herlev Hospital, Denmark.Participants: An age- and sex-stratified sample of 970 persons aged 30 to 60 years of age drawn from a sample randomly selected from the background population.Interventions: Not applicable.Measurements and Results: Sleep disurbances were evaluated by a combination of questionnaire and the use of prescription sleeping medical-increased whtn the transmission of blue light to the retina was low, even after correction for the effect of age and other confounding factors such as smoking habits, diabetes mellitus, gender, and the risk of ischemic heart disease (P < 0.0001).Conclusions: Filtration of blue light by the aging lens was significantly associated with an increased risk of sleep disturbances. We propose that this is a result of disturbance of photoentrainment of circadian rhythms.