Antihypertensive Agents
Antihypertensive Agents
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抗高血压药
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
Ö. Süzer
中科院分区：
文献类型：
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作者：
Ö. Süzer
多项研究表明，高血压患者的发病率和死亡率增加，适当的高血压治疗可以降低发病率和死亡率。然而，随着年龄的增长，降低血压的相对好处会减弱。2002年，Lewington等人发表了61项研究的100多万成年人的数据，这些研究涉及按年龄划分的收缩压(SBP)和舒张压(DBP)与中风和冠心病死亡率之间的关系。SBP和DBP与中风、冠心病和其他血管疾病的死亡率之间的关系是分级的和持续的，在SBP为115 mm Hg和DBP为75 mm Hg时风险最低(未报告较低的血压水平)，而在SBP为175 mm Hg和DBP为105 mm Hg时的风险最高(未报告较高水平)。然而，这些关联在年龄较大时较弱(见第2页图1)。1
Multiple studies have shown increased morbidity and mortality in patients with hypertension, with reduction in morbidity and mortality with appropriate treatment of the hypertension. With increasing age, however, the relative benefit of lowering blood pressure is attenuated. In 2002, Lewington et al published data from over 1 million adults from 61 studies on the associations between Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) and mortality from stroke and coronary heart disease by age. The associations between both SBP and DBP and mortality from stroke, coronary heart disease and other vascular disease were graded and continuous with the lowest risk at SBP of 115 mmHg and DBP of 75 mmHg (lower BP levels were not reported) and the highest risk at SBP of 175 mmHg and DBP of 105 mmHg (higher levels were not reported). However, these associations were weaker at older age (see Figure 1 on page 2). 1