Molecular-genetic and clinical characteristics of gliomas with astrocytic appearance and total 1p19q loss in a single institutional consecutive cohort.
Molecular-genetic and clinical characteristics of gliomas with astrocytic appearance and total 1p19q loss in a single institutional consecutive cohort.
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DOI：
10.18632/oncotarget.3869
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发表时间：
2015-06-30
期刊：
影响因子：
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通讯作者：
Yoshida K
中科院分区：
文献类型：
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作者：
Hayashi S;Sasaki H;Kimura T;Abe T;Nakamura T;Kitamura Y;Miwa T;Kameyama K;Hirose Y;Yoshida K
星形胶质细胞瘤1 p19 q缺失的预后意义尚未确定。我们从1990年至2010年在庆应义塾大学医院手术的218例WHO II/III级胶质瘤中收集了57例1 p19 q缺失的胶质瘤。根据WHO标准的机构诊断，这些肿瘤被归类为少突胶质细胞或“星形细胞”。评估了染色体拷贝数畸变（CNA）、IDH 1/2突变、MGMT启动子甲基化以及p53和ATRX的表达。比较两个组织学组的生存结局。在57例共缺失胶质瘤中，分别有37例、16例和4例被分类为少突胶质细胞、星形细胞和未分类。比较基因组杂交显示，虽然染色体7 q/7增益是更频繁的“星形细胞”胶质瘤，其他CNA发生在两组中的频率相似。没有一个星形胶质细胞胶质瘤显示p53积聚，在15个星形胶质细胞胶质瘤中的3个中发现ATRX丢失。共缺失少突胶质细胞和星形细胞胶质瘤患者的估计总生存期（OS）曲线重叠，中位OS分别为187和184个月。由一名病理学家进行的组织学重新评估显示了一致的结果。1 p19 q缺失的胶质瘤具有星形胶质细胞特征，其分子和生物学特征与少突胶质细胞肿瘤相似。
The prognostic significance of 1p19q loss in astrocytic gliomas has been inconclusive. We collected 57 gliomas with total 1p19q loss from among 218 cases of WHO grade-II/III gliomas operated at Keio University Hospital between 1990 and 2010. These tumors were classified as oligodendroglial or “astrocytic” by a WHO-criteria-based institutional diagnosis. Chromosomal copy number aberrations (CNAs), IDH 1/2 mutations, MGMT promoter methylation, and expression of p53 and ATRX were assessed. Survival outcome was compared between the two histological groups. Of the 57 codeleted gliomas, 37, 16, and four were classified as oligodendroglial, “astrocytic”, and unclassified, respectively. Comparative genomic hybridization revealed that although chromosome 7q/7 gain was more frequent in “astrocytic” gliomas, other CNAs occurred at a similar frequency in both groups. None of the “astrocytic” gliomas showed p53 accumulation, and ATRX loss was found in three of the 15 “astrocytic” gliomas. The estimated overall survival (OS) curves in the patients with codeleted oligodendroglial and “astrocytic” gliomas overlapped, and the median OS was 187 and 184 months, respectively. Histopathological re-assessment by a single pathologist showed consistent results. Gliomas with total 1p19q loss with “astrocytic” features have molecular and biological characteristics comparable to those of oligodendroglial tumors.