Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations.
Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations.
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DOI：
10.1093/nar/gkq1128
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发表时间：
2011-01
影响因子：
14.9
通讯作者：
Jones AR
中科院分区：
文献类型：
--
作者：
Gonzalez-Galarza FF;Christmas S;Middleton D;Jones AR
等位基因频率网络数据库（www.allelefrequencies.net）是一个在线储存库，包含不同人群中免疫基因及其相应等位基因的频率信息。在与免疫系统反应相关的基因和等位基因中观察到的广泛变异性及其在移植、疾病关联研究和人群多样性中的意义导致了该电子资源的开发。目前，该系统包含来自608 813个个体中的1133个群体的数据，这些数据关于来自不同多态性区域的基因的频率，例如人类白细胞抗原、巨噬细胞免疫球蛋白样受体、主要组织相容性复合物I类链相关基因和一些细胞因子基因多态性。该项目旨在创建一个用于存储频率数据的中央源，并为个人提供一套生物信息学工具，以分析这些变异在全球人群中的发生情况。该资源已被用于各种各样的情况下，包括临床应用（组织相容性，免疫学，流行病学和药物遗传学）和人口遗传学。人口信息、频率数据和搜索工具可通过该网站免费获取。
The allele frequency net database (http://www.allelefrequencies.net) is an online repository that contains information on the frequencies of immune genes and their corresponding alleles in different populations. The extensive variability observed in genes and alleles related to the immune system response and its significance in transplantation, disease association studies and diversity in populations led to the development of this electronic resource. At present, the system contains data from 1133 populations in 608 813 individuals on the frequency of genes from different polymorphic regions such as human leukocyte antigens, killer-cell immunoglobulin-like receptors, major histocompatibility complex Class I chain-related genes and a number of cytokine gene polymorphisms. The project was designed to create a central source for the storage of frequency data and provide individuals with a set of bioinformatics tools to analyze the occurrence of these variants in worldwide populations. The resource has been used in a wide variety of contexts, including clinical applications (histocompatibility, immunology, epidemiology and pharmacogenetics) and population genetics. Demographic information, frequency data and searching tools can be freely accessed through the website.