Uptake and release of ciprofloxacin-HCl from conventional and silicone hydrogel contact lens materials
Uptake and release of ciprofloxacin-HCl from conventional and silicone hydrogel contact lens materials
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DOI：
10.1097/icl.0b013e3181812ba2
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发表时间：
2008-09-01
影响因子：
2.3
通讯作者：
Jones, Lyndon
中科院分区：
文献类型：
--
作者：
Hui, Alex;Boone, Adrienne;Jones, Lyndon
目标.研究抗生素盐酸环丙沙星在传统和硅水凝胶镜片中的摄取和释放特性，并评价其作为治疗药物递送装置的潜力。方法.将9种不同的软性接触透镜材料在34 ℃下浸泡在0.3%环丙沙星-HCl溶液中。使用荧光分光光度法，通过24小时内的浓度变化来测量晶状体中药物的摄取。然后将镜片置于缓冲盐水溶液中，并使用分光光度法测量药物从镜片中的释放。结果药物释放从lotrafilcon A镜片的0.016 +/- 0.004 mg/透镜至etafilcon A镜片的0.42 +/- 0.03 mg/透镜不等，平均值为0.133 mg/透镜。与硅胶水凝胶相比，研究中使用的3种传统镜片释放的药物量具有统计学显著差异。药物释放非常迅速。对于大多数透镜，药物释放在不超过10分钟后达到稳定状态。大多数镜片能够释放足够的药物，以达到对大多数耐药性眼部病原体的最低抑制浓度90。发现在生理pH下的释放阶段，环丙沙星在etafilcon A镜片上大量沉淀。虽然balafilcon A从硅水凝胶材料中释放的药物最多，但所有材料释放药物的速度都太快，无法有效用作药物递送装置。
Objectives. To investigate the uptake and release characteristics of the antibiotic ciprofloxacin-HCl in conventional and silicone hydrogel lenses, and evaluate their potential as therapeutic drug delivery devices. Methods. Nine differing soft contact lens materials were soaked in a 0.3% ciprofloxacin-HCl solution at 34 degrees C. The uptake of the drug into the lenses was measured by the change in concentration over 24 hours using fluorescence spectrophotometry. The lenses were then placed in a buffered saline solution, and the release of the drug from the lenses was also measured using spectrophotometry. Results. The release of drug varied from 0.016 +/- 0.004 mg/lens for lotrafilcon A lenses to 0.42 +/- 0.03 mg/lens for etafilcon A lenses, with an average of 0.133 mg/lens. The 3 conventional lenses used in the study released a statistically significantly different amount of drug when compared with the silicone hydrogels. The release of drug was very rapid. with drug release reaching a plateau after no more than 10 minutes for the majority of the lenses. The majority of the lenses were able to release enough drug to achieve minimum inhibitory concentration 90 for most resistant ocular pathogens. Ciprofloxacin was found to heavily precipitate on the etafilcon A lenses during the release phase at physiologic pH. Conclusion. While balafilcon A released the most drug from the silicone hydrogel materials, all materials released the drug too quickly to be effective as drug delivery devices.