MR first pass perfusion of benign and malignant cardiac tumours-significant differences and diagnostic accuracy
MR first pass perfusion of benign and malignant cardiac tumours-significant differences and diagnostic accuracy
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DOI：
10.1007/s00330-011-2245-9
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发表时间：
2012-01-01
影响因子：
5.9
通讯作者：
Huber, A. M.
中科院分区：
文献类型：
--
作者：
Bauner, K. U.;Sourbron, S.;Huber, A. M.
为了确定磁共振（MR）首过灌注的诊断价值，在良性和恶性心脏肿瘤的分化。24例心脏肿瘤（11恶性，组织病理学相关性存在于所有情况下）进行了检查，使用MRI。除了形态序列的饱和恢复T1 w-GRE技术实施肿瘤灌注。评估肿瘤组织的最大相对信号增强（RSE[%]）和RSE t曲线的斜率（slopeRSE[%/s]）。使用t检验来确定良性和恶性肿瘤之间的显著差异。计算了检测恶性病变的敏感性和特异性，并与单纯基于形态学图像评估的敏感性和特异性进行了比较，恶性心脏肿瘤的RSE和斜率RSE显著高于良性病变（p < 0.001和p < 0.001）。RSE和slopeRSE鉴别恶性病变的敏感性和特异性分别为100%和84.6%和100%和92.3%，截断值分别为80%和6%/s。单纯形态学诊断恶性病变的敏感性和特异性分别为90.9%和69.2%。与单纯的形态学检查相比，恶性心脏肿块的诊断具有更高的敏感性和特异性，MRI通常可以将恶性心脏肿瘤与良性肿块区分开来，结合形态学检查和动态首过灌注有助于鉴别恶性心脏肿块。MR首过灌注有助于关于心脏肿瘤的有用诊断信息。
To determine the diagnostic value of magnetic resonance (MR) first pass perfusion in the differentiation of benign and malignant cardiac tumours.24 patients with cardiac tumours (11 malignant, histopathological correlation present in all cases) were examined using MRI. In addition to morphological sequences a saturation-recovery T1w-GRE technique was implemented for tumour perfusion. The maximum relative signal enhancement (RSE[%]) and the slope of the RSEt-curve (slopeRSE[%/s]) of tumour tissue were assessed. A t-test was used to identify significant differences between benign and malignant tumours. Sensitivities and specificities were calculated for detection of malignant lesions and were compared with the sensitivity and specificity based on solely morphological image assessment.The RSE and slopeRSE of malignant cardiac tumours were significantly higher compared with benign lesions (p < 0.001 and p < 0.001). The calculated sensitivities and specificities of RSE and slopeRSE for identification of malignant lesions were 100% and 84.6% and 100% and 92.3%, respectively with cut-off values of 80% and 6%/s. The sensitivity and specificity for identification of malignant lesions on the basis of morphological imaging alone were 90.9% and 69.2%.With first pass perfusion, malignant cardiac masses can be identified with higher sensitivity and specificity compared with morphological image assessment alone.Malignant cardiac tumours can usually be differentiated from benign masses by MRI.Combining morphologic imaging with dynamic first pass perfusion assists this differentiation.MR first pass perfusion contributes useful diagnostic information about cardiac tumours.