Evidence that brief stress may induce the acute phase response in rats.
Evidence that brief stress may induce the acute phase response in rats.
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有证据表明短暂的应激可能会诱发大鼠的急性期反应。
DOI：
10.1152/ajpregu.1997.273.6.r1998
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Maier,SF
中科院分区：
文献类型：
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作者：
Deak,T;Meriwether,JL;Fleshner,M;Spencer,RL;Abouhamze,A;Moldawer,LL;Grahn,RE;Watkins,LR;Maier,SF
将大鼠暴露于单次不可避免的尾部电击（IS）会在 24 小时后减少皮质类固醇结合球蛋白（CBG）（Fleshner 等人，Endocrinology136：5336-5342，1995）。目前的实验检查了CBG的减少是否受到可控尾部电击和相同的不可控制尾部电击的不同影响，是否由IS诱导的糖皮质激素升高介导，或者反映了IS诱导的急性期反应的激活以及IS是否产生发烧。结果表明：1) 在可逃脱的尾部电击或束缚 IS 的反应中观察到 CBG 的同等减少，2) 在接受基础皮质类固醇替代的大鼠中，IS 诱导的 CBG 减少不会被接受基础皮质类固醇替代或通过 RU-38486 预处理的大鼠所阻断，并且 3) IS 似乎激活急性期反应，因为 IS 降低了急性期阴性反应物 (CBG) 的血清水平，增加了急性期阳性反应物（触珠蛋白和结合珠蛋白）的血清水平。 α1-酸性糖蛋白），并在 20-24 小时后增加核心体温。
Exposing rats to a single session of inescapable tail shock (IS) reduces corticosteroid binding globulin (CBG) 24 h later (Fleshner et al.,Endocrinology136: 5336–5342, 1995). The present experiments examined whether reductions in CBG are differentially affected by controllable vs. identical uncontrollable tail shock, are mediated by IS-induced glucocorticoid elevation, or reflect IS-induced activation of the acute phase response and whether IS produces fever. The results demonstrate that1) equivalent reductions in CBG are observed in response to escapable tail shock or yoked IS,2) IS-induced CBG reduction is not blocked by adrenalectomy in rats that receive basal corticosteroid replacement or by pretreatment with RU-38486, and3) IS appears to activate the acute phase response, since IS reduces serum levels of an acute-phase negative reactant (CBG), increases serum levels of acute-phase positive reactants (haptoglobin and α1-acid glycoprotein), and increases core body temperature 20–24 h later.