Annual Incidence of Nephrolithiasis among Children and Adults in South Carolina from 1997 to 2012
Annual Incidence of Nephrolithiasis among Children and Adults in South Carolina from 1997 to 2012
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DOI：
10.2215/cjn.07610715
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发表时间：
2016-03-01
影响因子：
9.8
通讯作者：
Furth, Susan L.
中科院分区：
文献类型：
--
作者：
Tasian, Gregory E.;Ross, Michelle E.;Furth, Susan L.
背景和目的在美国肾结石的患病率已大幅增加，但最近的变化，发病率方面的年龄，性别和种族没有得到很好的表征。本研究探讨了时间趋势的年度发病率和累积风险肾结石的儿童和成人生活在南卡罗来纳州超过16 years periods.Design，设置，参与者和测量我们进行了一项基于人口的，重复的横断面研究，使用美国人口普查和南卡罗来纳州医疗遭遇的数据，其中捕获所有的急诊室访问，手术，并在该州的招生。估计了1997年至2012年南卡罗来纳州肾结石的年发病率，并使用线性混合模型估计年龄、性别和种族组的发病率比。结果在4，625，364名高危人群中，152，925名患者因肾结石接受急诊、住院或手术治疗。1997年至2012年，肾结石的平均年发病率每年增加1%，从每10万人206例增加到239例。在各年龄组中，15 - 19岁年龄组的发病率增加最多，每5年发病率增加26%（发病率比，1.26; 95%置信区间，1.22 - 1.29）。调整年龄和种族后，女性发病率每5年增加15%（发病率比，1.15; 95%置信区间，1.14至1.16），但男性保持稳定。与白人相比，黑人的发病率每5年增加15%以上（发病率比，1.15; 95%置信区间，1.14至1.17）。这些变化的发病率导致在儿童期肾结石的风险增加一倍，并在一生中肾结石的风险增加45%的妇女在研究period.Conclusions肾结石的发病率增加了年轻患者，特别是妇女，和黑人。
Background and objectives The prevalence of nephrolithiasis in the United States has increased substantially, but recent changes in incidence with respect to age, sex, and race are not well characterized. This study examined temporal trends in the annual incidence and cumulative risk of nephrolithiasis among children and adults living in South Carolina over a 16-year period.Design, setting, participants, & measurements We performed a population-based, repeated cross sectional study using the US Census and South Carolina Medical Encounter data, which capture all emergency department visits, surgeries, and admissions in the state. The annual incidence of nephrolithiasis in South Carolina from 1997 to 2012 was estimated, and linear mixed models were used to estimate incidence rate ratios for age, sex, and racial groups. The cumulative risk of nephrolithiasis during childhood and over the lifetime was estimated for males and females in 1997 and 2012.Results Among an at-risk population of 4,625,364 people, 152,925 unique patients received emergency, inpatient, or surgical care for nephrolithiasis. Between 1997 and 2012, the mean annual incidence of nephrolithiasis increased 1% annually from 206 to 239 per 100,000 persons. Among age groups, the greatest increase was observed among 15-19 year olds, in whom incidence increased 26% per 5 years (incidence rate ratio, 1.26; 95% confidence interval, 1.22 to 1.29). Adjusting for age and race, incidence increased 15% per 5 years among females (incidence rate ratio, 1.15; 95% confidence interval, 1.14 to 1.16) but remained stable for males. The incidence among blacks increased 15% more per 5 years compared with whites (incidence rate ratio, 1.15; 95% confidence interval, 1.14 to 1.17). These changes in incidence resulted in doubling of the risk of nephrolithiasis during childhood and a 45% increase in the lifetime risk of nephrolithiasis for women over the study period.Conclusions The incidence of kidney stones has increased among young patients, particularly women, and blacks.