Aldo-keto reductases in norepinephrine metabolism.
Aldo-keto reductases in norepinephrine metabolism.
复制标题
去甲肾上腺素代谢中的醛酮还原酶。
DOI：
10.1007/978-1-4615-4735-8_57
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发表时间：
1999
影响因子：
--
通讯作者：
Kador,PF
中科院分区：
文献类型：
--
作者：
Sato,S;Kawamura,M;Eisenhofer,G;Kopin,IJ;Fujisawa,S;Kador,PF
Monoamine oxidase (MAO, EC 1.4.3.4) and catechol-O-methyltransferease (COMT, EC 2.1.1.6) are the two primary enzymes responsible for the first step of the metabolism of the catecholamines epinephrine, norepinephrine and dopamine. Catecholamines and their methylated metabolites, produced by COMT, are metabolized to the corresponding aldehyde intermediates by MAO. In the subsequent second step these aldehydes are removed through either their oxidation to acids by aldehyde dehydrogenase (EC 1.2.1.3) or their reduction to alcohols by aldehyde reductase (Kopin, 1985). Here, we focus on the metabolism of norepinephrine and summarize evidences that aldose reductase is the key enzyme responsible for the metabolism of norepinephrine.
