Microbeam radiation therapy
Microbeam radiation therapy
复制标题
微束放射治疗
DOI：
10.1117/12.368185
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
H. Blattmann
中科院分区：
文献类型：
--
作者：
J. Laissue;N. Lyubimova;H. Wagner;D. W. Archer;D. Slatkin;M. Di Michiel;C. Némoz;M. Renier;E. Brauer;P. Spanne;Jan;K. Dixon;H. Blattmann
脊椎动物的中枢神经系统，即使在未发育成熟的时候，对显微镜下狭窄的、多束平行的、平面的x射线束的损伤也表现出非凡的抵抗力。这种微束可以抑制和消融成熟大鼠脑中的立即致死的胶质瘤，而对成熟脑组织和神经功能几乎没有损害或没有损害。在三岁以下的人类婴儿中，恶性脑肿瘤的潜在姑息性常规宽束放射治疗充满了破坏靶向肿瘤周围未成熟脑组织功能成熟的危险，因此很少实施。其他种类的治疗方法对这种肿瘤往往是不够的。我们认为微束放射治疗（MRT）可能有助于缓解这种情况。摇摆器产生的同步加速器X射线在20世纪90年代初首次用于布鲁克海文国家实验室的国家同步加速器光源的实验性微平面束（微束）放射治疗（MRT）。我们现在描述MRT研究取得的进展，到目前为止，使用未成年和成年大鼠在法国格勒诺布尔的欧洲同步辐射设施照射，并在研究所病理学的伯尔尼大学。
The central nervous system of vertebrates, even when immature, displays extraordinary resistance to damage by microscopically narrow, multiple, parallel, planar beams of x rays. Imminently lethal gliosarcomas in the brains of mature rats can be inhibited and ablated by such microbeams with little or no harm to mature brain tissues and neurological function. Potentially palliative, conventional wide-beam radiotherapy of malignant brain tumors in human infants under three years of age is so fraught with the danger of disrupting the functional maturation of immature brain tissues around the targeted tumor that it is implemented infrequently. Other kinds of therapy for such tumors are often inadequate. We suggest that microbeam radiation therapy (MRT) might help to alleviate the situation. Wiggler-generated synchrotron x-rays were first used for experimental microplanar beam (microbeam) radiation therapy (MRT) at Brookhaven National Laboratory's National Synchrotron Light Source in the early 1990s. We now describe the progress achieved in MRT research to date using immature and adult rats irradiated at the European Synchrotron Radiation Facility in Grenoble, France, and investigated thereafter at the Institute of Pathology of the University of Bern.