Action sites of antiallergic drugs on human neutrophils.
Action sites of antiallergic drugs on human neutrophils.
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抗过敏药物对人中性粒细胞的作用位点。
DOI：
--
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
K. Takanaka
中科院分区：
文献类型：
--
作者：
K. Taniguchi;Y. Masuda;K. Takanaka
通过测定白三烯B4的形成、花生四烯酸的释放和超氧化物的生成，研究了抗过敏药物（氮唑elastine、oxatomide、曲尼司特、repirinast和amlexanox）对人中性粒细胞的抑制作用位点。本研究得到的结果如下：(i)被钙离子载体（A23187）激活的中性粒细胞形成白三烯B4被所有类型的抗过敏药物有效抑制，尽管所需浓度在20-200微米范围内。（ii）活性细胞释放的花生四烯酸被归类为基本抗过敏药物的氮杂elastine和oxatomide减少。酸性抗过敏剂如利匹那司、氨lexanox和曲尼司特则能促进花生四烯酸的释放。（iii）被12-肉豆蔻酸酯- 13-醋酸酯或n-甲酰基-蛋氨酸-亮基-苯丙氨酸激活的中性粒细胞产生的几代超氧化物仅被基本抗过敏药物有效地减少。
Sites of the inhibitory action of antiallergic drugs (azelastine, oxatomide, tranilast, repirinast and amlexanox) on human neutrophils were investigated by measuring leukotriene B4 formation, arachidonic acid release and superoxide generation. Results obtained in this study were as follows: (i) Formations of leukotriene B4 by neutrophils activated with a calcium ionophore (A23187) were effectively inhibited by all types of antiallergic drugs examined here, although the required concentrations were within a range of 20-200 microM. (ii) Releases of arachidonic acid from activated cells were diminished by azelastine and oxatomide that were classified as basic antiallergic drugs. On the contrary, acidic antiallergic agents including repirinast, amlexanox and tranilast enhanced the arachidonic acid liberation. (iii) Generations of superoxide from neutrophils activated with either phorbol 12-myristate 13-acetate or n-formyl-methionyl-leucyl-phenylalanine were effectively diminished only by the basic antiallergic drugs.
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白三烯C4和D4对人支气管粘膜糖蛋白和溶菌酶分泌的影响。
DOI：
10.1016/0090-6980(83)90101-6
发表时间：
1983
期刊：
Prostaglandins
影响因子：
--
作者：
Coles,SJ;Neill,KH;Reid,LM;Austen,KF;Nii,Y;Corey,EJ;Lewis,RA
通讯作者：
Lewis,RA
DOI：
10.1073/pnas.77.7.4354
发表时间：
1980-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
DRAZEN, JM;AUSTEN, KF;COREY, EJ
通讯作者：
COREY, EJ
在无细胞系统中激活人中性粒细胞的呼吸爆发酶。
DOI：
10.1172/jci111884
发表时间：
1985
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
McPhail,LC;Shirley,PS;Clayton,CC;Snyderman,R
通讯作者：
Snyderman,R
影响因子：
5.8
作者：
O'Flaherty,JT
通讯作者：
O'Flaherty,JT