Strontium Incorporation on Microspheres of Alginate/β-tricalcium Phosphate as Delivery Matrices
Strontium Incorporation on Microspheres of Alginate/β-tricalcium Phosphate as Delivery Matrices
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DOI：
10.1590/s1516-14392014000400021
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发表时间：
2014-08-01
期刊：
影响因子：
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通讯作者：
Leão, Maria Helena Miguez Rocha
中科院分区：
文献类型：
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作者：
Moreira, Ana Paula Duarte;Sader, Márcia Soares;Leão, Maria Helena Miguez Rocha
已知锶（Sr）对骨重建的机制有积极影响。因此，磷酸钙生物陶瓷与含锶的藻酸盐基质结合，由于锶的逐渐释放，可以改善骨再生。这项工作的目的是将锶藻酸盐（ALG）/β-磷酸三钙（β-TCP）的微球，并评估在pH值为4.0和7.4的缓冲溶液中的锶离子的体外释放。在这项研究中，氯化锶被用作交联剂和锶源。能量色散谱（EDS）表明，锶主要是在所产生的微球的表面纳入。体外释锶实验表明，在pH 7.4条件下，由于锶在微球表面的位置，锶的释放速度可达24 h。在pH 4.0时，由于β-TCP溶解，钙和锶都被释放。
Strontium (Sr) is known to positively affect the mechanism of bone remodelling. Consequently, calcium phosphate bioceramics associated with alginate matrices containing strontium could improve bone regeneration due to gradual strontium release. This work aims to incorporate Sr on microspheres of alginate (ALG)/beta-tricalcium phosphate (beta-TCP) and evaluates the in vitro release of strontium ions into a buffer solution at pH 4.0 and 7.4. In this study, strontium chloride was employed as a cross-linking agent and Sr source. Energy dispersive spectroscopy (EDS) showed that strontium was incorporated mainly at the surface of the microspheres produced. The in vitro experiments revealed that there is a rapid strontium release up to 24 h at pH 7.4 due to Sr location on microspheres' surface. At pH 4.0 both calcium and strontium were released due to the beta-TCP dissolution.