ORAL INFECTION OF CULICOIDES-VARIIPENNIS WITH BLUETONGUE VIRUS - DEVELOPMENT OF SUSCEPTIBLE AND RESISTANT LINES FROM A COLONY POPULATION
ORAL INFECTION OF CULICOIDES-VARIIPENNIS WITH BLUETONGUE VIRUS - DEVELOPMENT OF SUSCEPTIBLE AND RESISTANT LINES FROM A COLONY POPULATION
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DOI：
10.1093/jmedent/11.3.316
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发表时间：
1974-01-01
影响因子：
2.1
通讯作者：
FOSTER, NM
中科院分区：
文献类型：
--
作者：
JONES, RH;FOSTER, NM
通过对变异库蚊（Culicoides variipennis Coquillett）索诺拉株000系（中间敏感率为30%）进行交配选择，选育出4个品系，其中3个品系敏感，1个品系抗性。这4个系中的3个系在其13、27和15代菌落维持中的单次感染血粉的平均感染率为92、63和2%;来自2次重复感染血粉的数据表明，2个敏感系的敏感率为100%，抗性系为高度抗性。这些数据表明，至少有2种遗传机制控制口腔感染病毒的易感性：第一个快速分离，似乎是单基因控制与显性等位基因的电阻;第二个机制控制的阈值的反应。我们的信息表明，虫媒病毒病可以通过降低媒介物种的媒介能力而不控制物种本身来控制。
Four lines ofCulicoides variipennis(Coquillett), 3 susceptible and 1 resistant to oral infection with bluetongue virus, were developed through a genetic selection program of selected matings from a parent colony (SONORA strain, 000 line) with an intermediate susceptibility rate of 30%. Three of these 4 lines had mean infection rates of 92, 63, and 2% for a single infective blood meal for their 13, 27, and 15 generations of colony maintenance; data from 2 repeated infective blood meals indicated that the 2 susceptible lines had susceptibility rates of 100% and that the resistant line was highly resistant. The data indicate that at least 2 genetic mechanisms governed susceptibility to oral infection with the virus: the 1st segregated rapidly and appeared to be single gene control with the dominant allele for resistance; a 2nd mechanism controlled the threshold of response. Our information suggests that an arbovirus disease might be controlled by lowering the vector capacity of a vector species without controlling the species itself.