Rhodium/Gold Dual Catalysis in Carbene sp 2 C−H Functionalization/Conia‐ene Cascade for the Stereoselective Synthesis of Diverse Spirocarbocycles
Rhodium/Gold Dual Catalysis in Carbene sp 2 C−H Functionalization/Conia‐ene Cascade for the Stereoselective Synthesis of Diverse Spirocarbocycles
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DOI：
10.1002/adsc.201900079
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发表时间：
2019-06
影响因子：
5.4
通讯作者：
A. Hunter;Kiran Chinthapally;Anae I. Bain;Joseph C Stevens;I. Sharma
中科院分区：
文献类型：
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作者：
A. Hunter;Kiran Chinthapally;Anae I. Bain;Joseph C Stevens;I. Sharma
介绍了一种Rh（II）/Au（I）催化的卡宾级联立体选择性合成多种螺碳环化合物的方法。级联反应涉及铑卡宾引发的sp 2C-H官能化，然后是金催化的Conia-ene环化。级联反应适应各种芳基取代基以及环的大小，并以高非对映选择性进行，从而获得不同的螺碳环。
A Rh(II)/Au(I) catalyzed carbene cascade approach for the stereoselective synthesis of diverse spirocarbocycles is described. The cascade reaction involves a rhodium carbene initiatedsp2C−H functionalization followed by a gold catalyzed Conia‐ene cyclization. The cascade reaction accommodates a variety of aryl substituents as well as ring sizes and proceeds with high diastereoselectivity providing access to diverse spirocarbocycles.