Serum glycated albumin to haemoglobin A1C ratio can distinguish fulminant type 1 diabetes mellitus from type 2 diabetes mellitus
Serum glycated albumin to haemoglobin A1C ratio can distinguish fulminant type 1 diabetes mellitus from type 2 diabetes mellitus
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DOI：
10.1258/acb.2010.009234
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发表时间：
2010-07-01
影响因子：
2.2
通讯作者：
Kobayashi, Tetsuro
中科院分区：
文献类型：
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作者：
Koga, Masafumi;Murai, Jun;Kobayashi, Tetsuro
背景：暴发性1型糖尿病（FT 1DM）是1型糖尿病的一种亚型，2000年首次作为一种疾病实体报道。由于急性胰腺细胞破坏导致的首次发作的酮症酸中毒使得FT 1DM的早期诊断和治疗成为强制性的。在FT 1DM的早期，血红蛋白（Hb）A（1C）水平没有明显升高。本研究探讨了反映血糖急性短期变化的血清糖化白蛋白（GA）作为FT 1DM发病时新的临床指标。方法：受试者包括35例在首次访视时接受HbA（1C）和血清GA测量的FT 1DM患者和42例2型糖尿病（T2 DM）患者，42例FT 1DM患者中有41例HbA（1C）3.2（结论：FT 1DM患者血清GA水平明显高于T2 DM患者，而HbA 1C水平明显低于T2 DM患者。因此，在糖尿病治疗前的首次访视时，可通过GA/HbA（1C）比值将FT 1DM与未经治疗的T2 DM区分开来。
Background: Fulminant type 1 diabetes mellitus (FT1DM), a subtype of type 1 diabetes mellitus, was first reported as a disease entity in 2000. Ketoacidosis at initial onset due to acute pancreatic cell destruction makes early diagnosis and treatment for FT1DM mandatory. In the early period of FT1DM, haemoglobin (Hb)A(1C) levels are not markedly elevated. This study investigated serum glycated albumin (GA), which reflects acute short-term changes in plasma glucose, as a new clinical index for FT1DM at disease onset.Methods: Subjects comprised 35 patients with FT1DM who had undergone measurement of HbA(1C) and serum GA at initial visit and 42 patients with type 2 diabetes mellitus (T2DM) with HbA(1C) 3.2 in 41 of 42 FT1DM patients (98%), compared with only one of 32 T2DM patients (3%).Conclusions: Serum GA is significantly higher in FT1DM than in T2DM, whereas HbA(1C) is significantly lower. FT1DM can thus be distinguished from untreated T2DM by GA/HbA(1C) ratio at initial visit before treatment for diabetes.