Trans-synaptic transmission of vesicular Wnt signals through Evi/Wntless.
Trans-synaptic transmission of vesicular Wnt signals through Evi/Wntless.
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DOI：
10.1016/j.cell.2009.07.051
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发表时间：
2009-10-16
期刊：
影响因子：
64.5
通讯作者：
Budnik V
中科院分区：
文献类型：
--
作者：
Korkut C;Ataman B;Ramachandran P;Ashley J;Barria R;Gherbesi N;Budnik V
Wnts play pivotal roles during development and in the mature nervous system. However, the mechanism by which Wnts traffic between cells has remained elusive. Here we demonstrate a novel mechanism of Wnt transmission through release of exosome-like vesicles containing the Wnt-binding protein Evenness Interrupted/Wntless/Sprinter (Evi/Wls/Srt). We show that at the Drosophila larval neuromuscular junction (NMJ), presynaptic vesicular release of Evi is required for the secretion of the Wnt, Wingless (Wg). We also show that Evi acts cell-autonomously in the postsynaptic Wnt-receiving cell to target dGRIP, a Wg-receptor-interacting protein, to postsynaptic sites. Upon Evi loss of function, dGRIP is not properly targeted to synaptic sites, interfering with postsynaptic Wnt signal transduction. These findings uncover a previously unknown cellular mechanism by which a secreted Wnt is transported across synapses by Evi-containing vesicles, and reveal novel trafficking functions of Evi in both the Wnt-producing and the Wnt-receiving cell.
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影响因子：
5.3
作者：
Mendoza-Topaz, Carolina;Urra, Francisco;Sierralta, Jimena
通讯作者：
Sierralta, Jimena
影响因子：
16.2
作者：
Ataman, Bulent;Ashley, James;Budnik, Vivian
通讯作者：
Budnik, Vivian
影响因子：
5.3
作者：
Franco, B;Bogdanik, L;Grau, Y
通讯作者：
Grau, Y
影响因子：
9.2
作者：
Pielage, J;Fetter, RD;Davis, GW
通讯作者：
Davis, GW
DOI：
10.1523/jneurosci.0164-08.2008
发表时间：
2008-10-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Miech C;Pauer HU;He X;Schwarz TL
通讯作者：
Schwarz TL