Genome wide association study of cholesterol and poly- and monounsaturated fatty acids, protein, and mineral content of beef from crossbred cattle
Genome wide association study of cholesterol and poly- and monounsaturated fatty acids, protein, and mineral content of beef from crossbred cattle
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DOI：
10.1016/j.meatsci.2014.07.030
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发表时间：
2014-12-01
期刊：
影响因子：
7.1
通讯作者：
Spangler, M. L.
中科院分区：
文献类型：
--
作者：
Ahlberg, C. M.;Schiermiester, L. N.;Spangler, M. L.
目的是确定肉牛胆固醇（CH）、多不饱和脂肪酸（PUFA）、单不饱和脂肪酸（MUFA）、蛋白质和矿物质的BovineSNP 50 v2 BeadChip所解释的变异，并确定携带这些性状变异的主要等位基因变异的染色体区域。收获在BTA 2上的失活肌肉生长抑制素等位基因处分离的杂交阉牛和小母牛（n = 236），并从M. semitendinosus和M.用于营养分析。全基因组关联分析采用贝叶斯C算法。由此产生的后验遗传力（SD）估计值范围为0.43（0.10）至0.71（0.08）的脂质性状和0.05（0.08）至0.75（0.06）的矿物质性状。在切割过程中，CH、MUFA和PUFA的基因组估计育种值（GEBV）之间的相关性相似。所有性状的前0.5% 1-Mb窗口解释了高达9.93%的SNP方差。切之间和脂肪酸的不同测量尺度之间确实存在轻微差异。(C)2014爱思唯尔有限公司版权所有。
The objectives were to determine the variation explained by the BovineSNP50v2 BeadChip for cholesterol (CH), polyunsaturated fatty acids (PUFA), monounsaturated fatty acids (MUFA), protein, and minerals in beef cattle, and to identify chromosomal regions that harbor major allelic variants underlying the variation of these traits. Crossbred steers and heifers (n = 236) segregating at the inactive myostatin allele on BTA2 were harvested and steaks were sampled from the M. semitendinosus and the M. longissimus thoracis et lumborum for nutrient analysis. A Bayes C algorithm was employed in genome-wide association analysis. The resulting posterior heritability (SD) estimates ranged from 0.43 (0.10) to 0.71 (0.08) for lipid traits and 0.05 (0.08) to 0.75 (0.06) for mineral traits. Across cuts, correlations between genomic estimated breeding values (GEBV) were similar for CH, MUFA and PUFA. The top 0.5% 1-Mb windows for all traits explained up to 9.93% of the SNP variance. Slight differences did exist between cuts and between different measurement scales of fatty acids. (C) 2014 Elsevier Ltd. All rights reserved.