Expression of c-Fos-like immunoreactive neurons in the supratrigeminal region in the rat following noxious stimulation of the orofacial tissues
Expression of c-Fos-like immunoreactive neurons in the supratrigeminal region in the rat following noxious stimulation of the orofacial tissues
复制标题
口面部组织有害刺激后大鼠三叉神经上区 c-Fos 样免疫反应神经元的表达
DOI：
10.1016/s0304-3940(02)01163-1
复制
发表时间：
2002
影响因子：
2.5
通讯作者：
K. Tanne
中科院分区：
文献类型：
--
作者：
Mineo Watanabe;E. Tanaka;Mika Nishi;T. Iwabe;Y. Hattori;S. Suemune;K. Tanne
本研究旨在通过免疫组织化学方法研究对牙齿施加机械力、对舌头进行机械捏捏以及将多聚甲醛注射到牙周膜和咬肌后，三叉神经运动核周围神经元中 c-Fos 的表达。在应用除捏舌头之外的所有这些刺激后，在同侧三叉上区发现了少量 c-Fos 样免疫反应性 (Fos-LI) 神经元。在所有实验动物的尾亚核浅层的许多神经元中也检测到了 c-Fos 表达。尾亚核和三叉上区中 c-Fos 的诱导表明三叉上区的 Fos-LI 神经元参与口内伤害性信号的处理。
This study was conducted to investigate immunohistochemically the expression of c-Fos in neurons around the trigeminal motor nucleus following application of mechanical force to a tooth, a mechanical pinch to the tongue, and paraformaldehyde injection into the periodontal ligament and masseter muscle. Following the application of all of these stimuli except pinching the tongue, a small number of c-Fos-like immunoreactive (Fos-LI) neurons were found in the ipsilateral supratrigeminal region. c-Fos expression was also detected in numerous neurons in the superficial laminae of the subnucleus caudalis in all experimental animals. Induction of c-Fos in the subnucleus caudalis and the supratrigeminal region indicates that Fos-LI neurons in the supratrigeminal region are involved in the processing of intraoral nociceptive signals.