Osteosarcoma (osteogenic sarcoma).
Osteosarcoma (osteogenic sarcoma).
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DOI：
10.1186/1750-1172-2-6
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发表时间：
2007-01-23
影响因子：
3.7
通讯作者：
Picci P
中科院分区：
文献类型：
--
作者：
Picci P
骨肉瘤是一种原发性骨骼恶性肿瘤，其特征是肿瘤细胞直接形成未成熟的骨或类骨组织。典型骨肉瘤是一种罕见的高度恶性肿瘤（占所有恶性肿瘤的0.2%），估计发病率为3例/百万人/年。骨肉瘤主要发生于长骨，很少发生于软组织。发病年龄从10岁到25岁不等。x线平片、计算机断层扫描、磁共振成像、血管造影和动态骨显像用于诊断、评估肿瘤累及程度和决定手术类型，如有必要，还可用于重建类型。多年前，所有骨肉瘤患者都采用截肢治疗，但治愈率低于10%，几乎所有患者在确诊后一年内死亡。今天，对于发病的局部骨肉瘤（80%的病例），在专门的骨肿瘤中心进行术前和术后化疗并进行手术治疗，患者的治愈率在60%至70%之间。90%以上的患者采用保守手术（保肢）。位于中轴骨骼的肿瘤和发病时就有转移的患者预后更为严重（治愈率约为30%）。
Osteosarcoma is a primary malignant tumour of the skeleton characterised by the direct formation of immature bone or osteoid tissue by the tumour cells. The classic osteosarcoma is a rare (0.2% of all malignant tumours) highly malignant tumour, with an estimated incidence of 3 cases/million population/year. Osteosarcoma arises predominantly in the long bones and rarely in the soft tissues. The age at presentation ranges from 10 to 25 years of age. Plain radiographs, computed tomography, magnetic resonance imaging, angiography and dynamic bone scintigraphy are used for diagnosis, evaluation the extent of tumour involvement and decision of the type of operation and, if necessary, the type of reconstruction. Years ago, all patients with osteosarcoma were treated by amputation but the cure rate was under 10% and almost all patients died within a year from diagnosis. Today, for localised osteosarcoma at onset (80% of cases) treated in specialized bone tumour centres with pre- and postoperative chemotherapy associated with surgery, the percentage of patients cured varies between 60% and 70%. Surgery is conservative (limb salvage) in more than 90% of patients. Prognosis is more severe (cure rate about 30%) for tumours located in the axial skeleton and in patients with metastasis at onset.
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影响因子：
45.3
作者：
MCINTYRE, JF;SMITHSORENSEN, B;GEBHARDT, MC
通讯作者：
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