Microdamage: A cell transducing mechanism based on ruptured osteocyte processes
Microdamage: A cell transducing mechanism based on ruptured osteocyte processes
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DOI：
10.1016/j.jbiomech.2005.06.006
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发表时间：
2006-01-01
影响因子：
2.4
通讯作者：
Taylor, David
中科院分区：
文献类型：
--
作者：
Hazenberg, Jan G.;Freeley, Michael;Taylor, David
由于潜在的病理疾病，如骨质疏松症、骨质减少症，或由于关节置换后负荷的改变，骨骼比正常人更容易受到微损伤的积累，进行剧烈运动的运动员也是如此[Stromsoe， 2004]。骨质疏松症的骨折固定问题。损伤35,107-113]。实验证据表明，骨适应与微损伤和细胞活性增加有关。在这项工作中，我们研究了微裂纹检测是否与细胞材料本身由于裂纹面位移而破裂有关。使用特定的细胞染色技术，证实了相对裂纹位移能够撕裂相邻骨细胞之间的细胞过程。在位移较小的裂纹尖端附近没有发现破裂的细胞过程。裂纹张开和剪切位移引起的细胞过程破裂是骨检测和估计微裂纹大小的一种可行的新机制。破裂的细胞过程可以直接在细胞外基质中分泌被动和主动成分，引发修复反应。(c) 2005年Elsevier Ltd出版
As a result of underlying pathological diseases, such as osteoporosis, osteopenia, or due to altered loading after joint replacements, bones become more susceptible to microdamage accumulation than those of normal human beings, as are those of athletes who undertake strenuous exercise [Stromsoe, 2004. Fracture fixation problems in osteoporosis. Injury 35, 107-113]. Experimental evidence has linked bone adaptation to microdamage, and to increased cell activity. In this work, we investigated whether microcrack detection is related to rupturing of the cellular material itself due to crack face displacements. Using specific cell staining techniques, it was confirmed that relative crack displacements are capable of tearing cell processes between neighbouring osteocytes. No ruptured cell processes were found near the crack tip where the displacements are less. Rupturing of cell processes due to crack opening and shear displacement is a feasible new mechanism by which bone can detect and estimate the size of a microcrack. Ruptured cell processes may directly secrete passive and active components in the extracellular matrix, triggering a repair response. (c) 2005 Published by Elsevier Ltd.