Circulating hepatocyte growth factor as a diagnostic marker of thrombus formation in patients with cerebral infarction
Circulating hepatocyte growth factor as a diagnostic marker of thrombus formation in patients with cerebral infarction
复制标题
DOI：
10.1253/circj.66.216
复制
发表时间：
2002-02-01
影响因子：
3.3
通讯作者：
Sasayama, S
中科院分区：
文献类型：
--
作者：
Matsumori, A;Takano, H;Sasayama, S
由于动脉血栓形成，急性心肌梗死早期循环中肝细胞生长因子(HGF)水平升高。本研究的目的是使用一种新的敏感的酶联免疫吸附试验来研究脑梗塞患者循环中的HGF是否增加。对32例脑梗塞患者于入院时及发病后第2、3、7、14天测定循环HGF。20例患者中有10例(50%)在发病后6 h内血清HGF水平超过正常值+2SD(329 pg/ml)，32例患者中有15例(47%)在发病24 h内血浆D-二聚体升高。连续测量的16名患者的HGF水平在整个研究期间持续上升。提示循环HGF是脑梗塞的可靠早期标志物，这一新的灵敏的HGF检测方法可能有助于脑血栓的诊断。
Circulating levels of hepatocyte growth factor (HGF) are increased in the early stage of an acute myocardial infarction because of arterial thrombosis. The purpose of this study was to use a new sensitive enzyme-linked immunosorbent assay to investigate whether circulating HGF is increased in patients with cerebral infarction. Circulating HGF was measured in 32 patients with cerebral infarction on admission to hospital and on days 2, 3, 7 and 14 after the onset of symptoms. Serum HGF levels exceeded the mean value +2SD (329 pg/ml) measured in controls in 10 of 20 patients (50%) within 6 h after onset and in 15 of 32 patients (47%) within 24 h. Plasma D-dimer was increased in more than half of the patients with elevated HGF values. HGF levels in 16 patients who were measured serially were persistently increased throughout the study period. The results suggests that circulating HGF is a reliable early marker of cerebral infarction, and that this new sensitive HGF assay may be useful for diagnosing cerebral thrombosis.