Impact of Physical Inactivity on Adipose Tissue Low-Grade Inflammation in First-Degree Relatives of Type 2 Diabetic Patients
Impact of Physical Inactivity on Adipose Tissue Low-Grade Inflammation in First-Degree Relatives of Type 2 Diabetic Patients
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DOI：
10.2337/dc11-0631
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发表时间：
2011-10-01
期刊：
影响因子：
16.2
通讯作者：
Stallknecht, Bente
中科院分区：
文献类型：
--
作者：
Hojbjerre, Lise;Sonne, Mette Paulli;Stallknecht, Bente
糖尿病患者的一级亲属（FDR）在缺乏体力活动时可能会出现胰岛素抵抗、肥胖和2型糖尿病的风险不成比例地升高，这在某种程度上可能涉及低度炎症。我们调查了受试者谁是非肥胖的FDR显示之前或之后暴露于短期physical inactivity.RESEARCH设计和方法，我们研究了13名健康的FDR受试者和20名对照（CON）受试者的年龄，性别和BM I之前和之后10天的卧床休息（BR）的迹象。采用高胰岛素正葡萄糖钳夹法测定胰岛素敏感性。在皮下腹部（SCAAT）和股脂肪组织的动脉血和微透析液中测量关键的低度炎症介质。在BR之前，FOR受试者表现出胰岛素抵抗，血浆C反应蛋白、瘦素和单核细胞趋化蛋白（MCP）-1升高，白细胞介素（IL）-6和MCP-1高表达，以及瘦素和瘦素的低表达。FOR受试者通过降低血浆脂联素和IL-10表达以及增加IL-10和肿瘤坏死因子-α的血浆表达对BR作出反应。与此相反，CON主题BR通过增加血浆脂联素和脂联素的表达和减少SCAAT微透析leptin.CONCLUSIONS-Young和非肥胖FDR的2型糖尿病患者表现出低度炎症，这是进一步和不成比例地加剧时，暴露于体力活动。这项研究为2型糖尿病风险增加的人应该避免即使是短时间的身体活动的概念提供了支持。
OBJECTIVE-First-degree relatives (FDRs) of patients with type 2 diabetes may exhibit a disproportionately elevated risk of developing insulin resistance, obesity, and type 2 diabetes when exposed to physical inactivity, which to some unknown extent may involve low-grade inflammation. We investigated whether subjects who are nonobese FDRs show signs of low-grade inflammation before or after exposure to short-term physical inactivity.RESEARCH DESIGN AND METHODS-We studied 13 healthy FDR subjects and 20 control (CON) subjects matched for age, sex, and BM I before and after 10 days of bed rest (BR). Insulin sensitivity was measured by the hyperinsulinemic euglycemic clamp. Key low-grade inflammation mediators were measured in arterial blood and microdialysate from subcutaneous abdominal (SCAAT) and femoral adipose tissue. Adipokine mRNA expression was determined in scAAT.RESULTS-Before BR, FOR subjects displayed insulin resistance, elevated plasma C-reactive protein, leptin, and monocyte chemoattractant protein (MCP)-1, high interleukin (IL)-6, and MCP-1 expressions, as well as tow aliponect in and leptin expressions. FOR subjects responded to BR by decreasing plasma acliponectin and IL-10 expression and increasing plasma expression of IL-10 and tumor necrosis factor-alpha. In contrast, CON subjects responded to BR by increasing plasma acliponectin and adiponectin expression and by decreasing SCAAT microdialysate leptin.CONCLUSIONS-Young and nonobese FDR of patients with type 2 diabetes exhibit low-grade inflammation, which is further and disproportionately aggravated when exposed to physical inactivity. The study provides support for the notion that people at increased risk of type 2 diabetes should avoid even short periods of physical inactivity.