Vitamin B12 deficiency in Caenorhabditis elegans results in loss of fertility, extended life cycle, and reduced lifespan
Vitamin B12 deficiency in Caenorhabditis elegans results in loss of fertility, extended life cycle, and reduced lifespan
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DOI：
10.1016/j.fob.2013.01.008
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发表时间：
2013-01-01
期刊：
影响因子：
2.6
通讯作者：
Watanabe, Fumio
中科院分区：
文献类型：
--
作者：
Bito, Tomohiro;Matsunaga, Yohei;Watanabe, Fumio
维生素B-12缺乏与发育障碍、代谢异常和神经病变有关；然而，有关的机制仍然知之甚少。在缺乏B-12的条件下生长的秀丽隐杆线虫五代会出现严重的B-12缺乏，并伴有各种表型，包括产卵能力下降（不育）、生命周期延长（生长迟缓）和寿命缩短。这些表型类似于哺乳动物缺乏B-12的后果，并且可以在秀丽隐杆线虫中仅在15天内诱导。因此，秀丽隐杆线虫是研究维生素缺乏诱导的生物过程的合适动物模型。(C) 2013年作者。由爱思唯尔B.V.代表欧洲生化学会联合会出版。版权所有。
Vitamin B-12 (B-12) deficiency has been linked to developmental disorders, metabolic abnormalities, and neuropathy; however, the mechanisms involved remain poorly understood. Caenorhabditis elegans grown under B-12-deficient conditions for five generations develop severe B-12 deficiency associated with various phenotypes that include decreased egg-laying capacity (infertility), prolonged life cycle (growth retardation), and reduced lifespan. These phenotypes resemble the consequences of B-12 deficiency in mammals, and can be induced in C. elegans in only 15 days. Thus, C. elegans is a suitable animal model for studying the biological processes induced by vitamin deficiency. (C) 2013 The Authors. Published by Elsevier B.V. on behalf of Federation of European Biochemical Societies. All rights reserved.