The interaction of procaine with the nonmyelinated nerve axon.
The interaction of procaine with the nonmyelinated nerve axon.
复制标题
普鲁卡因与非髓鞘神经轴突的相互作用。
DOI：
10.1139/o72-023
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发表时间：
1972
期刊：
影响因子：
--
通讯作者：
S. Tay
中科院分区：
文献类型：
--
作者：
H. Simpkins;E. Panko;S. Tay
普鲁卡因与无髓神经轴突的腿Homarus americanus的相互作用被发现产生膜的脂质结构的构象变化。用溴化乙酰胆碱处理神经后也观察到这种构象变化，但用以下任何一种局部麻醉剂都没有观察到这种变化：利多卡因、卡波替尼、丙胺卡因和纽哌卡因。普鲁卡因是一种有效的乙酰胆碱酯酶抑制剂，而其他麻醉药在相同浓度下的作用很小。
The interaction of procaine with the nonmyelinated nerve axon from the legs of Homarus americanus was found to produce a conformational change in the lipid structure of the membrane. This conformational change was also observed after treatment of the nerve with acetylcholine bromide but not with any of the following local anesthetics:lidocaine, carbocaine, prilocaine, and nupercaine. It was also found that procaine is a potent inhibitor of acetylcholinesterase whereas the other anesthetics at the same concentration had little effect.