New limits in ultrasensitive trace detection by surface enhanced Raman scattering (SERS)
New limits in ultrasensitive trace detection by surface enhanced Raman scattering (SERS)
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DOI：
10.1016/s0009-2614(03)00821-2
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发表时间：
2003-06-25
影响因子：
2.8
通讯作者：
Gallop, JC
中科院分区：
文献类型：
--
作者：
Etchegoin, P;Maher, RC;Gallop, JC
我们利用非共振表面增强拉曼散射（Sers）技术，研究了溶液中浓度低至10（-18）阿托摩尔分数的化学示踪的可能性。实验证明，与罗丹明6 G溶解在水中。基于我们的研究结果，我们提出了一种技术，用于计数少量的Sers活性分子在微液滴的液体。有人认为，通过选择适当的Sers增强条件，该技术可以使用和实施作为一种常规的分析方法，具有前所未有的检测能力，用于监测和跟踪的重要家庭的生物分子。(C)2003 Elsevier Science B. V.保留所有权利。
We show the possibility of chemical tracing in solution down to a concentration of a fraction of an atto mol (10(-18)) by means of non-resonant surface enhanced Raman scattering (SERS). The experiments are demonstrated with rhodamine 6G dissolved in water. Based on our results here, we propose a technique for counting a small number of SERS active molecules in micro-droplets of liquid. It is argued that, by choosing the appropriate SERS enhancement condition, the technique could be used and implemented as a routine analytical method with unprecedented detection capabilities for the monitoring and tracing of important families of biomolecules. (C) 2003 Elsevier Science B.V. All rights reserved.