Transmission of olfactory information between three populations of neurons in the antennal lobe of the fly
Transmission of olfactory information between three populations of neurons in the antennal lobe of the fly
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DOI：
10.1016/s0896-6273(02)00975-3
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发表时间：
2002-10-24
期刊：
影响因子：
16.2
通讯作者：
Miesenböck, G
中科院分区：
文献类型：
--
作者：
Ng, M;Roorda, RD;Miesenböck, G
在果蝇的触角叶中，三类神经元形成突触，果蝇是脊椎动物嗅球的昆虫对应物：嗅觉受体神经元，投射神经元和抑制性局部中间神经元。我们有针对性地将突触传递的遗传编码的光学报告者定位到这些类别的神经元中的每一个，并可视化了对自然气味的群体反应。嗅觉受体神经元的气味特异性集合的激活导致穿过肾小球突触中继的投射神经元的对称集合的激活。几乎所有兴奋的肾小球都接受来自局部中间神经元的抑制性输入。这种输入的程度，气味特异性，部分interglomerular起源表明，抑制电路组装组合在气味介绍。这些电路可以作为动态模板，从传入活动模式中提取高阶特征。
Three classes of neurons form synapses in the antennal lobe of Drosophila, the insect counterpart of the vertebrate olfactory bulb: olfactory receptor neurons, projection neurons, and inhibitory local interneurons., We have targeted a genetically encoded optical reporter of synaptic transmission to each of these classes of neurons and visualized population responses to natural odors. The activation of an odor-specific ensemble of olfactory receptor neurons leads, to the activation of a symmetric ensemble of projection neurons across the glomerular synaptic relay. Virtually all excited glomeruli receive inhibitory input from local interneurons. The extent, odor specificity, and partly interglomerular origin of this input suggest that inhibitory circuits assemble combinatorially during odor presentations. These circuits may serve as dynamic templates that extract higher order features from afferent activity patterns.