The effects of blood-brain barrier disruption on glial cell function in multiple sclerosis
The effects of blood-brain barrier disruption on glial cell function in multiple sclerosis
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DOI：
10.1042/bst0370329
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发表时间：
2009-02-01
影响因子：
3.9
通讯作者：
Fitzgerald, Una
中科院分区：
文献类型：
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作者：
McQuaid, Stephen;Cunnea, Paula;Fitzgerald, Una
血脑屏障功能障碍是多发性硬化症的主要标志。在过去的十年中，我们实验室的研究表明，131313通透性的增加与脑毛细血管内皮细胞中TJ（紧密连接）蛋白的表达减少有关。结果显示TJ异常在活动性病变中最常见（42%的血管受影响），但也存在于非活动性病变（23%）和MS正常白质（13%）中。重要的是，TJ异常也与血清蛋白纤维蛋白原的泄漏呈正相关，而纤维蛋白原最近被证明是小胶质细胞的激活剂。TJ异常和由此产生的病变和非病变白质的血管通透性可能损害组织的稳态，这可能影响疾病的进展、修复机制和药物输送。
Dysfunction of the BBB (blood-brain barrier) is a major hallmark of MS (multiple sclerosis). Studies in our laboratories over the last decade have shown that increased 131313 permeability is associated with decreased expression of TJ (tight junction) proteins in brain capillary endothelial cells. Results have revealed that TJ abnormalities were most common in active lesions (42% of vessels affected), but were also present in inactive lesions (23%) and in MS normal-appearing white matter (13%). Importantly, TJ abnormality was also positively associated with leakage of the serum protein fibrinogen which has recently been shown to be an activator of microglia. TJ abnormality and the resultant vascular permeability in both lesional and non-lesional white matter may impair tissue homoeostasis, which may have effects on disease progression, repair mechanisms and drug delivery.