Insights from Genome-Wide Association Analyses of Nonalcoholic Fatty Liver Disease.
Insights from Genome-Wide Association Analyses of Nonalcoholic Fatty Liver Disease.
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DOI：
10.1055/s-0035-1567870
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发表时间：
2015-11
影响因子：
4.2
通讯作者：
Speliotes EK
中科院分区：
文献类型：
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作者：
Kahali B;Halligan B;Speliotes EK
非酒精性脂肪性肝病（NAFLD）是由肝脂肪变性引起的，在没有过量饮酒的情况下，可进展为非酒精性脂肪性肝炎、纤维化/肝硬化和肝细胞癌。到2020年，非酒精性脂肪肝将成为全球肝脏疾病的头号原因。非酒精性脂肪肝与肥胖和其他代谢性疾病如糖尿病、高脂血症和心血管疾病的相关性虽然不完全，但确切地说，这些疾病之一如何导致其他代谢性疾病的发展，现在才被阐明。NAFLD和相关代谢疾病的发展在人群中受到遗传影响，最近的全基因组关联研究（GWAS）发现了与这些疾病相关的遗传变异。这些GWAS相关的变异不仅可以帮助我们识别NAFLD高风险个体，还可以更好地了解其病理生理学，以便我们将来可以为这种疾病和相关代谢疾病开发更有效的治疗方法。
Nonalcoholic fatty liver disease (NAFLD) is caused by hepatic steatosis, which can progress to nonalcoholic steatohepatitis, fibrosis/cirrhosis, and hepatocellular carcinoma in the absence of excessive alcohol consumption. Nonalcoholic fatty liver disease will become the number one cause of liver disease worldwide by 2020. Nonalcoholic fatty liver disease is correlated albeit imperfectly with obesity and other metabolic diseases such as diabetes, hyperlipidemia, and cardiovascular disease, but exactly how having one of these diseases contributes to the development of other metabolic diseases is only now being elucidated. Development of NAFLD and related metabolic diseases is genetically influenced in the population, and recent genome-wide association studies (GWASs) have discovered genetic variants that associate with these diseases. These GWAS-associated variants cannot only help us to identify individuals at high risk of developing NAFLD, but also to better understand its pathophysiology so that we can develop more effective treatments for this disease and related metabolic diseases in the future.